Insulators and imprinting from flies to mammals

The nuclear factor CTCF has been shown to be necessary for the maintenance of genetic imprinting at the mammalian H19/Igf2 locus. MacDonald and colleagues now report in BMC Biology that the mechanisms responsible for maintaining the imprinted state in Drosophila may be evolutionarily conserved and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Chunhui, Corces, Victor G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912829/
https://www.ncbi.nlm.nih.gov/pubmed/20687908
http://dx.doi.org/10.1186/1741-7007-8-104
Descripción
Sumario:The nuclear factor CTCF has been shown to be necessary for the maintenance of genetic imprinting at the mammalian H19/Igf2 locus. MacDonald and colleagues now report in BMC Biology that the mechanisms responsible for maintaining the imprinted state in Drosophila may be evolutionarily conserved and that CTCF may also play a critical role in this process. See research article http://www.biomedcentral.com/1741-7007/8/105

Ejemplares similares