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Peripheral blood T Regulatory cell counts may not predict transplant rejection
BACKGROUND: Recent evidence shows that allograft survival rates show a positive correlation with the number of circulating T regulatory cells (Tregs). This study investigated both the number and the cytokine profiles exhibited by Foxp3(+ )Tregs in blood, spleen and lymph nodes of Lewis rat recipient...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912834/ https://www.ncbi.nlm.nih.gov/pubmed/20633262 http://dx.doi.org/10.1186/1471-2172-11-40 |
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author | Huang, Yuchuan Shan, Juan Zhang, Chuntao Zhang, Jie Feng, Li Li, Shengfu Li, Youping |
author_facet | Huang, Yuchuan Shan, Juan Zhang, Chuntao Zhang, Jie Feng, Li Li, Shengfu Li, Youping |
author_sort | Huang, Yuchuan |
collection | PubMed |
description | BACKGROUND: Recent evidence shows that allograft survival rates show a positive correlation with the number of circulating T regulatory cells (Tregs). This study investigated both the number and the cytokine profiles exhibited by Foxp3(+ )Tregs in blood, spleen and lymph nodes of Lewis rat recipients of BN rat cardiac allografts after a single-dose of Rapamycin (RAPA). RESULTS: Rats were divided into three groups: control group (containing healthy control and acute rejection group), and recipients treated with a single dose of RAPA on either Day 1 (1D group)or Day 3 (3D group) post-transplant. We analyzed the number of Foxp3+Tregs and the expression of Foxp3 and cytokines in the peripheral blood and the peripheral lymphoid tissues. No difference was found in the numbers of circulating Foxp3+ Tregs between these three groups. RAPA administration significantly increased Foxp3 expression in peripheral lymphoid tissues after a single dose of RAPA on Day 3 post-transplant. Foxp3+Tregs inhibited the activity of effector T cells (T(eff)) via the secretion of TGF-β1. CONCLUSION: The number of Tregs in the recipient's blood may not be a good predictor of transplant rejection. Foxp3+Tregs inhibit the activity of T(eff )cells mainly in the peripheral lymphoid tissues. |
format | Text |
id | pubmed-2912834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29128342010-07-31 Peripheral blood T Regulatory cell counts may not predict transplant rejection Huang, Yuchuan Shan, Juan Zhang, Chuntao Zhang, Jie Feng, Li Li, Shengfu Li, Youping BMC Immunol Research Article BACKGROUND: Recent evidence shows that allograft survival rates show a positive correlation with the number of circulating T regulatory cells (Tregs). This study investigated both the number and the cytokine profiles exhibited by Foxp3(+ )Tregs in blood, spleen and lymph nodes of Lewis rat recipients of BN rat cardiac allografts after a single-dose of Rapamycin (RAPA). RESULTS: Rats were divided into three groups: control group (containing healthy control and acute rejection group), and recipients treated with a single dose of RAPA on either Day 1 (1D group)or Day 3 (3D group) post-transplant. We analyzed the number of Foxp3+Tregs and the expression of Foxp3 and cytokines in the peripheral blood and the peripheral lymphoid tissues. No difference was found in the numbers of circulating Foxp3+ Tregs between these three groups. RAPA administration significantly increased Foxp3 expression in peripheral lymphoid tissues after a single dose of RAPA on Day 3 post-transplant. Foxp3+Tregs inhibited the activity of effector T cells (T(eff)) via the secretion of TGF-β1. CONCLUSION: The number of Tregs in the recipient's blood may not be a good predictor of transplant rejection. Foxp3+Tregs inhibit the activity of T(eff )cells mainly in the peripheral lymphoid tissues. BioMed Central 2010-07-15 /pmc/articles/PMC2912834/ /pubmed/20633262 http://dx.doi.org/10.1186/1471-2172-11-40 Text en Copyright ©2010 Huang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Huang, Yuchuan Shan, Juan Zhang, Chuntao Zhang, Jie Feng, Li Li, Shengfu Li, Youping Peripheral blood T Regulatory cell counts may not predict transplant rejection |
title | Peripheral blood T Regulatory cell counts may not predict transplant rejection |
title_full | Peripheral blood T Regulatory cell counts may not predict transplant rejection |
title_fullStr | Peripheral blood T Regulatory cell counts may not predict transplant rejection |
title_full_unstemmed | Peripheral blood T Regulatory cell counts may not predict transplant rejection |
title_short | Peripheral blood T Regulatory cell counts may not predict transplant rejection |
title_sort | peripheral blood t regulatory cell counts may not predict transplant rejection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912834/ https://www.ncbi.nlm.nih.gov/pubmed/20633262 http://dx.doi.org/10.1186/1471-2172-11-40 |
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