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Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists

BACKGROUND: DNA methylation and histone acetylation are epigenetic modifications that act as regulators of gene expression. Aberrant epigenetic gene silencing in tumours is a frequent event, yet the factors which dictate which genes are targeted for inactivation are unknown. DNA methylation and hist...

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Detalles Bibliográficos
Autores principales:	Mossman, David, Kim, Kyu-Tae, Scott, Rodney J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912869/ https://www.ncbi.nlm.nih.gov/pubmed/20618997 http://dx.doi.org/10.1186/1471-2407-10-366

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