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Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis

BACKGROUND: Pancreatic ductal adenocarcinoma shows a distinct apoptosis resistance, which contributes significantly to the aggressive nature of this tumor and constrains the effectiveness of new therapeutic strategies. Apoptosis resistance is determined by the net balance of the cells pro-and anti-a...

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Detalles Bibliográficos
Autores principales:	Rückert, Felix, Samm, Nicole, Lehner, Anne-Kathrin, Saeger, Hans-Detlev, Grützmann, Robert, Pilarsky, Christian
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912871/ https://www.ncbi.nlm.nih.gov/pubmed/20646298 http://dx.doi.org/10.1186/1471-2407-10-379

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