Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis

High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle reg...

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Detalles Bibliográficos
Autores principales: Feller, Liviu, Wood, Neil H, Khammissa, Razia AG, Lemmer, Johan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912877/
https://www.ncbi.nlm.nih.gov/pubmed/20633287
http://dx.doi.org/10.1186/1746-160X-6-14
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author Feller, Liviu
Wood, Neil H
Khammissa, Razia AG
Lemmer, Johan
author_facet Feller, Liviu
Wood, Neil H
Khammissa, Razia AG
Lemmer, Johan
author_sort Feller, Liviu
collection PubMed
description High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.
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spelling pubmed-29128772010-07-31 Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis Feller, Liviu Wood, Neil H Khammissa, Razia AG Lemmer, Johan Head Face Med Review High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma. BioMed Central 2010-07-15 /pmc/articles/PMC2912877/ /pubmed/20633287 http://dx.doi.org/10.1186/1746-160X-6-14 Text en Copyright ©2010 Feller et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Feller, Liviu
Wood, Neil H
Khammissa, Razia AG
Lemmer, Johan
Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis
title Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis
title_full Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis
title_fullStr Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis
title_full_unstemmed Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis
title_short Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis
title_sort human papillomavirus-mediated carcinogenesis and hpv-associated oral and oropharyngeal squamous cell carcinoma. part 1: human papillomavirus-mediated carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912877/
https://www.ncbi.nlm.nih.gov/pubmed/20633287
http://dx.doi.org/10.1186/1746-160X-6-14
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