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IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases
BACKGROUND: Prognosis assessment of patients with infectious and neoplastic disorders of the central nervous system (CNS) may still pose a challenge. In this retrospective cross-sectional study the prognostic value of basic cerebrospinal fluid (CSF) parameters in patients with bacterial meningitis,...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912906/ https://www.ncbi.nlm.nih.gov/pubmed/20618966 http://dx.doi.org/10.1186/1471-2334-10-202 |
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author | Lackner, Peter Guengoer, Elif Beer, Ronny Broessner, Gregor Helbok, Raimund Deisenhammer, Florian Schmutzhard, Erich Pfausler, Bettina |
author_facet | Lackner, Peter Guengoer, Elif Beer, Ronny Broessner, Gregor Helbok, Raimund Deisenhammer, Florian Schmutzhard, Erich Pfausler, Bettina |
author_sort | Lackner, Peter |
collection | PubMed |
description | BACKGROUND: Prognosis assessment of patients with infectious and neoplastic disorders of the central nervous system (CNS) may still pose a challenge. In this retrospective cross-sectional study the prognostic value of basic cerebrospinal fluid (CSF) parameters in patients with bacterial meningitis, viral meningoencephalitis and leptomeningeal metastases were evaluated. METHODS: White blood cell count, CSF/serum glucose ratio, protein, CSF/serum albumin quotient and Immunoglobulin indices for IgG, IgA and IgM were analyzed in 90 patients with bacterial meningitis, 117 patients with viral meningoencephalitis and 36 patients with leptomeningeal metastases in a total of 480 CSF samples. RESULTS: In the initial spinal tap, the IgG-index was the only independent predictor for unfavorable outcome (GOS < 5) in patients with infectious CNS diseases but not in patients with leptomeningeal metastases. The sensitivity and specificity of an IgG-index of 0.75 and higher for predicting unfavorable outcome was 40.9% and 80.8% in bacterial meningitis and 40% and 94.8% in viral meningoencephalitis, respectively. No significant associations between CSF parameters and outcome could be observed in follow-up CSF samples. CONCLUSION: The present study suggests that in infectious CNS diseases an elevated IgG-Index might be an additional marker for the early identification of patients at risk for neurological morbidity. |
format | Text |
id | pubmed-2912906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29129062010-07-31 IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases Lackner, Peter Guengoer, Elif Beer, Ronny Broessner, Gregor Helbok, Raimund Deisenhammer, Florian Schmutzhard, Erich Pfausler, Bettina BMC Infect Dis Research Article BACKGROUND: Prognosis assessment of patients with infectious and neoplastic disorders of the central nervous system (CNS) may still pose a challenge. In this retrospective cross-sectional study the prognostic value of basic cerebrospinal fluid (CSF) parameters in patients with bacterial meningitis, viral meningoencephalitis and leptomeningeal metastases were evaluated. METHODS: White blood cell count, CSF/serum glucose ratio, protein, CSF/serum albumin quotient and Immunoglobulin indices for IgG, IgA and IgM were analyzed in 90 patients with bacterial meningitis, 117 patients with viral meningoencephalitis and 36 patients with leptomeningeal metastases in a total of 480 CSF samples. RESULTS: In the initial spinal tap, the IgG-index was the only independent predictor for unfavorable outcome (GOS < 5) in patients with infectious CNS diseases but not in patients with leptomeningeal metastases. The sensitivity and specificity of an IgG-index of 0.75 and higher for predicting unfavorable outcome was 40.9% and 80.8% in bacterial meningitis and 40% and 94.8% in viral meningoencephalitis, respectively. No significant associations between CSF parameters and outcome could be observed in follow-up CSF samples. CONCLUSION: The present study suggests that in infectious CNS diseases an elevated IgG-Index might be an additional marker for the early identification of patients at risk for neurological morbidity. BioMed Central 2010-07-09 /pmc/articles/PMC2912906/ /pubmed/20618966 http://dx.doi.org/10.1186/1471-2334-10-202 Text en Copyright ©2010 Lackner et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lackner, Peter Guengoer, Elif Beer, Ronny Broessner, Gregor Helbok, Raimund Deisenhammer, Florian Schmutzhard, Erich Pfausler, Bettina IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases |
title | IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases |
title_full | IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases |
title_fullStr | IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases |
title_full_unstemmed | IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases |
title_short | IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases |
title_sort | igg-index predicts neurological morbidity in patients with infectious central nervous system diseases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912906/ https://www.ncbi.nlm.nih.gov/pubmed/20618966 http://dx.doi.org/10.1186/1471-2334-10-202 |
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