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High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar

BACKGROUND: Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae have spread worldwide but there are few reports on carriage in hospitals in low-income countries. ESBL-producing Enterobacteriaceae (ESBL-PE) have been increasingly isolated from nosocomial infections in Antananarivo, Mada...

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Autores principales: Andriatahina, Todisoa, Randrianirina, Frédérique, Hariniana, Eliosa Ratsima, Talarmin, Antoine, Raobijaona, Honoré, Buisson, Yves, Richard, Vincent
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912907/
https://www.ncbi.nlm.nih.gov/pubmed/20624313
http://dx.doi.org/10.1186/1471-2334-10-204
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author Andriatahina, Todisoa
Randrianirina, Frédérique
Hariniana, Eliosa Ratsima
Talarmin, Antoine
Raobijaona, Honoré
Buisson, Yves
Richard, Vincent
author_facet Andriatahina, Todisoa
Randrianirina, Frédérique
Hariniana, Eliosa Ratsima
Talarmin, Antoine
Raobijaona, Honoré
Buisson, Yves
Richard, Vincent
author_sort Andriatahina, Todisoa
collection PubMed
description BACKGROUND: Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae have spread worldwide but there are few reports on carriage in hospitals in low-income countries. ESBL-producing Enterobacteriaceae (ESBL-PE) have been increasingly isolated from nosocomial infections in Antananarivo, Madagascar. METHODS: we conducted a prevalence survey in a pediatric unit from March to April 2008 Patient rectal swabs were sampled on the first and the last day of hospitalization. Medical staff and environment were also sampled. Rectal and environmental swabs were immediately plated onto Drigalski agar supplemented with 3 mg/liter of ceftriaxon. RESULTS: Fecal carriage was detected in 21.2% of 244 infants on admission and 57.1% of 154 on discharge, after more than 48 hours of hospitalization (p < 0.001). The species most frequently detected on admission were Escherichia coli and Klebsiella pneumoniae (36.9%), whereas, on discharge, K. pneumoniae was the species most frequently detected (52.7%). ESBL-associated resistances were related to trimethoprim-sulfamethoxazole (91.3%), gentamicin (76.1%), ciprofloxacin (50.0%), but not to amikacin and imipenem. The increased prevalence of carriage during hospitalization was related to standard antimicrobial therapy. CONCLUSION: The significant emergence of multidrug-resistant enteric pathogens in Malagasy hospitals poses a serious health threat requiring the implementation of surveillance and control measures for nosocomial infections.
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spelling pubmed-29129072010-07-31 High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar Andriatahina, Todisoa Randrianirina, Frédérique Hariniana, Eliosa Ratsima Talarmin, Antoine Raobijaona, Honoré Buisson, Yves Richard, Vincent BMC Infect Dis Research Article BACKGROUND: Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae have spread worldwide but there are few reports on carriage in hospitals in low-income countries. ESBL-producing Enterobacteriaceae (ESBL-PE) have been increasingly isolated from nosocomial infections in Antananarivo, Madagascar. METHODS: we conducted a prevalence survey in a pediatric unit from March to April 2008 Patient rectal swabs were sampled on the first and the last day of hospitalization. Medical staff and environment were also sampled. Rectal and environmental swabs were immediately plated onto Drigalski agar supplemented with 3 mg/liter of ceftriaxon. RESULTS: Fecal carriage was detected in 21.2% of 244 infants on admission and 57.1% of 154 on discharge, after more than 48 hours of hospitalization (p < 0.001). The species most frequently detected on admission were Escherichia coli and Klebsiella pneumoniae (36.9%), whereas, on discharge, K. pneumoniae was the species most frequently detected (52.7%). ESBL-associated resistances were related to trimethoprim-sulfamethoxazole (91.3%), gentamicin (76.1%), ciprofloxacin (50.0%), but not to amikacin and imipenem. The increased prevalence of carriage during hospitalization was related to standard antimicrobial therapy. CONCLUSION: The significant emergence of multidrug-resistant enteric pathogens in Malagasy hospitals poses a serious health threat requiring the implementation of surveillance and control measures for nosocomial infections. BioMed Central 2010-07-12 /pmc/articles/PMC2912907/ /pubmed/20624313 http://dx.doi.org/10.1186/1471-2334-10-204 Text en Copyright ©2010 Andriatahina et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Andriatahina, Todisoa
Randrianirina, Frédérique
Hariniana, Eliosa Ratsima
Talarmin, Antoine
Raobijaona, Honoré
Buisson, Yves
Richard, Vincent
High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar
title High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar
title_full High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar
title_fullStr High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar
title_full_unstemmed High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar
title_short High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar
title_sort high prevalence of fecal carriage of extended-spectrum β-lactamase-producing escherichia coli and klebsiella pneumoniae in a pediatric unit in madagascar
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912907/
https://www.ncbi.nlm.nih.gov/pubmed/20624313
http://dx.doi.org/10.1186/1471-2334-10-204
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