Cargando…
Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants
OBJECTIVES: To compare three methods for evaluating treatment adherence in a 7-day controlled treatment period for malaria in children in Rwanda. METHODS: Fifty-six children (< 5 years) with malaria were recruited at the University Hospital of Butare, Rwanda. Patients were treated with quinine su...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912926/ https://www.ncbi.nlm.nih.gov/pubmed/20637094 http://dx.doi.org/10.1186/1475-2875-9-206 |
_version_ | 1782184653629685760 |
---|---|
author | Twagirumukiza, Marc Kayumba, Pierre Claver Kips, Jan G Vrijens, Bernard Stichele, Robert Vander Vervaet, Chris Remon, Jean Paul Van Bortel, M Luc |
author_facet | Twagirumukiza, Marc Kayumba, Pierre Claver Kips, Jan G Vrijens, Bernard Stichele, Robert Vander Vervaet, Chris Remon, Jean Paul Van Bortel, M Luc |
author_sort | Twagirumukiza, Marc |
collection | PubMed |
description | OBJECTIVES: To compare three methods for evaluating treatment adherence in a 7-day controlled treatment period for malaria in children in Rwanda. METHODS: Fifty-six children (< 5 years) with malaria were recruited at the University Hospital of Butare, Rwanda. Patients were treated with quinine sulfate, taste-masked, pellets during seven days: three days in hospital (in-patient) followed by a four-day out-patient period. Three methods to evaluate medication adherence among patients were compared: manual pill count of returned tablets, patient self-report and electronic pill-box monitoring. These pill-boxes were equipped with a microchip registering date and time of every opening. Medication adherence was defined as the proportion of prescribed doses taken. The inter-dose intervals were analysed as well. RESULTS: Medication adherence data were available for 54 of the 56 patients. Manual pill count and patient self-report yielded a medication adherence of 100% for the in- and out-patient treatment periods. Based on electronic pill-box monitoring, medication adherence during the seven-day treatment period was 90.5 ± 8.3%. Based on electronic pill-box monitoring inpatient medication adherence (99.3 ± 2.7%) was markedly higher (p < 0.03) than out-patient adherence (82.7 ± 14.7%), showing a clear difference between health workers' and consumers' medication adherence. CONCLUSION: Health workers' medication adherence was good. However, a significant lower medication adherence was observed for consumers' adherence in the outpatient setting. This was only detected by electronic pill-box monitoring. Therefore, this latter method is more accurate than the two other methods used in this study. |
format | Text |
id | pubmed-2912926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29129262010-07-31 Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants Twagirumukiza, Marc Kayumba, Pierre Claver Kips, Jan G Vrijens, Bernard Stichele, Robert Vander Vervaet, Chris Remon, Jean Paul Van Bortel, M Luc Malar J Research OBJECTIVES: To compare three methods for evaluating treatment adherence in a 7-day controlled treatment period for malaria in children in Rwanda. METHODS: Fifty-six children (< 5 years) with malaria were recruited at the University Hospital of Butare, Rwanda. Patients were treated with quinine sulfate, taste-masked, pellets during seven days: three days in hospital (in-patient) followed by a four-day out-patient period. Three methods to evaluate medication adherence among patients were compared: manual pill count of returned tablets, patient self-report and electronic pill-box monitoring. These pill-boxes were equipped with a microchip registering date and time of every opening. Medication adherence was defined as the proportion of prescribed doses taken. The inter-dose intervals were analysed as well. RESULTS: Medication adherence data were available for 54 of the 56 patients. Manual pill count and patient self-report yielded a medication adherence of 100% for the in- and out-patient treatment periods. Based on electronic pill-box monitoring, medication adherence during the seven-day treatment period was 90.5 ± 8.3%. Based on electronic pill-box monitoring inpatient medication adherence (99.3 ± 2.7%) was markedly higher (p < 0.03) than out-patient adherence (82.7 ± 14.7%), showing a clear difference between health workers' and consumers' medication adherence. CONCLUSION: Health workers' medication adherence was good. However, a significant lower medication adherence was observed for consumers' adherence in the outpatient setting. This was only detected by electronic pill-box monitoring. Therefore, this latter method is more accurate than the two other methods used in this study. BioMed Central 2010-07-16 /pmc/articles/PMC2912926/ /pubmed/20637094 http://dx.doi.org/10.1186/1475-2875-9-206 Text en Copyright ©2010 Twagirumukiza et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Twagirumukiza, Marc Kayumba, Pierre Claver Kips, Jan G Vrijens, Bernard Stichele, Robert Vander Vervaet, Chris Remon, Jean Paul Van Bortel, M Luc Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants |
title | Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants |
title_full | Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants |
title_fullStr | Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants |
title_full_unstemmed | Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants |
title_short | Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants |
title_sort | evaluation of medication adherence methods in the treatment of malaria in rwandan infants |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912926/ https://www.ncbi.nlm.nih.gov/pubmed/20637094 http://dx.doi.org/10.1186/1475-2875-9-206 |
work_keys_str_mv | AT twagirumukizamarc evaluationofmedicationadherencemethodsinthetreatmentofmalariainrwandaninfants AT kayumbapierreclaver evaluationofmedicationadherencemethodsinthetreatmentofmalariainrwandaninfants AT kipsjang evaluationofmedicationadherencemethodsinthetreatmentofmalariainrwandaninfants AT vrijensbernard evaluationofmedicationadherencemethodsinthetreatmentofmalariainrwandaninfants AT stichelerobertvander evaluationofmedicationadherencemethodsinthetreatmentofmalariainrwandaninfants AT vervaetchris evaluationofmedicationadherencemethodsinthetreatmentofmalariainrwandaninfants AT remonjeanpaul evaluationofmedicationadherencemethodsinthetreatmentofmalariainrwandaninfants AT vanbortelmluc evaluationofmedicationadherencemethodsinthetreatmentofmalariainrwandaninfants |