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Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis

PURPOSE: The purpose of this study was to evaluate the levels of neutrophil gelatinase-associated lipocalin (NGAL) in the aqueous humor in eyes with idiopathic acute anterior uveitis (AAU). METHODS: A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with idiopathic...

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Autores principales: Salom, David, Sanz-Marco, Empar, Mullor, Jose L., Lopez-Prats, Maria Jesus, Garcia-Delpech, Salvador, Udaondo, Patricia, Millan, Jose Maria, Arevalo, J. Fernando, Diaz-Llopis, Manuel
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913142/
https://www.ncbi.nlm.nih.gov/pubmed/20680102
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author Salom, David
Sanz-Marco, Empar
Mullor, Jose L.
Lopez-Prats, Maria Jesus
Garcia-Delpech, Salvador
Udaondo, Patricia
Millan, Jose Maria
Arevalo, J. Fernando
Diaz-Llopis, Manuel
author_facet Salom, David
Sanz-Marco, Empar
Mullor, Jose L.
Lopez-Prats, Maria Jesus
Garcia-Delpech, Salvador
Udaondo, Patricia
Millan, Jose Maria
Arevalo, J. Fernando
Diaz-Llopis, Manuel
author_sort Salom, David
collection PubMed
description PURPOSE: The purpose of this study was to evaluate the levels of neutrophil gelatinase-associated lipocalin (NGAL) in the aqueous humor in eyes with idiopathic acute anterior uveitis (AAU). METHODS: A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with idiopathic AAU. The control group included 20 aqueous samples from 20 patients about to undergo cataract surgery and without any other ocular or systemic diseases. The level of NGAL was determined with a commercially available ELISA kit. RESULTS: The concentration of NGAL in aqueous humor was markedly higher in patients with idiopathic AAU than in control subjects (Mann–Whitney U test, p<0.001). The level of NGAL was 139,197.38±183,426.36 (mean±SD) pg/ml in eyes with AAU and 3,169.96±1,595.78 pg/ml in the eyes of the control group. CONCLUSIONS: The aqueous humor NGAL level is increased in eyes with idiopathic AAU. These results imply that NGAL is associated with the regulation of inflammation in patients with AAU and could be used as a biomarker of ocular inflammation and immunomodulatory treatment response.
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spelling pubmed-29131422010-08-02 Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis Salom, David Sanz-Marco, Empar Mullor, Jose L. Lopez-Prats, Maria Jesus Garcia-Delpech, Salvador Udaondo, Patricia Millan, Jose Maria Arevalo, J. Fernando Diaz-Llopis, Manuel Mol Vis Research Article PURPOSE: The purpose of this study was to evaluate the levels of neutrophil gelatinase-associated lipocalin (NGAL) in the aqueous humor in eyes with idiopathic acute anterior uveitis (AAU). METHODS: A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with idiopathic AAU. The control group included 20 aqueous samples from 20 patients about to undergo cataract surgery and without any other ocular or systemic diseases. The level of NGAL was determined with a commercially available ELISA kit. RESULTS: The concentration of NGAL in aqueous humor was markedly higher in patients with idiopathic AAU than in control subjects (Mann–Whitney U test, p<0.001). The level of NGAL was 139,197.38±183,426.36 (mean±SD) pg/ml in eyes with AAU and 3,169.96±1,595.78 pg/ml in the eyes of the control group. CONCLUSIONS: The aqueous humor NGAL level is increased in eyes with idiopathic AAU. These results imply that NGAL is associated with the regulation of inflammation in patients with AAU and could be used as a biomarker of ocular inflammation and immunomodulatory treatment response. Molecular Vision 2010-07-29 /pmc/articles/PMC2913142/ /pubmed/20680102 Text en Copyright © 2010 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Salom, David
Sanz-Marco, Empar
Mullor, Jose L.
Lopez-Prats, Maria Jesus
Garcia-Delpech, Salvador
Udaondo, Patricia
Millan, Jose Maria
Arevalo, J. Fernando
Diaz-Llopis, Manuel
Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis
title Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis
title_full Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis
title_fullStr Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis
title_full_unstemmed Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis
title_short Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis
title_sort aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913142/
https://www.ncbi.nlm.nih.gov/pubmed/20680102
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