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A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

Assembly of a transcriptional and post-translational molecular interaction network in B cells, the human B-cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty pe...

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Autores principales: Lefebvre, Celine, Rajbhandari, Presha, Alvarez, Mariano J, Bandaru, Pradeep, Lim, Wei Keat, Sato, Mai, Wang, Kai, Sumazin, Pavel, Kustagi, Manjunath, Bisikirska, Brygida C, Basso, Katia, Beltrao, Pedro, Krogan, Nevan, Gautier, Jean, Dalla-Favera, Riccardo, Califano, Andrea
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913282/
https://www.ncbi.nlm.nih.gov/pubmed/20531406
http://dx.doi.org/10.1038/msb.2010.31
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author Lefebvre, Celine
Rajbhandari, Presha
Alvarez, Mariano J
Bandaru, Pradeep
Lim, Wei Keat
Sato, Mai
Wang, Kai
Sumazin, Pavel
Kustagi, Manjunath
Bisikirska, Brygida C
Basso, Katia
Beltrao, Pedro
Krogan, Nevan
Gautier, Jean
Dalla-Favera, Riccardo
Califano, Andrea
author_facet Lefebvre, Celine
Rajbhandari, Presha
Alvarez, Mariano J
Bandaru, Pradeep
Lim, Wei Keat
Sato, Mai
Wang, Kai
Sumazin, Pavel
Kustagi, Manjunath
Bisikirska, Brygida C
Basso, Katia
Beltrao, Pedro
Krogan, Nevan
Gautier, Jean
Dalla-Favera, Riccardo
Califano, Andrea
author_sort Lefebvre, Celine
collection PubMed
description Assembly of a transcriptional and post-translational molecular interaction network in B cells, the human B-cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre-replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues.
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spelling pubmed-29132822010-08-02 A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers Lefebvre, Celine Rajbhandari, Presha Alvarez, Mariano J Bandaru, Pradeep Lim, Wei Keat Sato, Mai Wang, Kai Sumazin, Pavel Kustagi, Manjunath Bisikirska, Brygida C Basso, Katia Beltrao, Pedro Krogan, Nevan Gautier, Jean Dalla-Favera, Riccardo Califano, Andrea Mol Syst Biol Article Assembly of a transcriptional and post-translational molecular interaction network in B cells, the human B-cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre-replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues. European Molecular Biology Organization 2010-06-08 /pmc/articles/PMC2913282/ /pubmed/20531406 http://dx.doi.org/10.1038/msb.2010.31 Text en Copyright © 2010, EMBO and Macmillan Publishers Limited https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation or the creation of derivative works without specific permission.
spellingShingle Article
Lefebvre, Celine
Rajbhandari, Presha
Alvarez, Mariano J
Bandaru, Pradeep
Lim, Wei Keat
Sato, Mai
Wang, Kai
Sumazin, Pavel
Kustagi, Manjunath
Bisikirska, Brygida C
Basso, Katia
Beltrao, Pedro
Krogan, Nevan
Gautier, Jean
Dalla-Favera, Riccardo
Califano, Andrea
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
title A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
title_full A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
title_fullStr A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
title_full_unstemmed A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
title_short A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
title_sort human b-cell interactome identifies myb and foxm1 as master regulators of proliferation in germinal centers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913282/
https://www.ncbi.nlm.nih.gov/pubmed/20531406
http://dx.doi.org/10.1038/msb.2010.31
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