Cargando…
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
To identify susceptibility loci for non-Hodgkin lymphoma (NHL) subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma (FL) in 1,465 FL cases/6,958 controls at 6p21.32 (rs10484561, rs7755224, r(2)=1.0; combined p-values=1.12×...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913472/ https://www.ncbi.nlm.nih.gov/pubmed/20639881 http://dx.doi.org/10.1038/ng.626 |
| _version_ | 1782184671472254976 |
|---|---|
| author | Conde, Lucia Halperin, Eran Akers, Nicholas K. Brown, Kevin M. Smedby, Karin E. Rothman, Nathaniel Nieters, Alexandra Slager, Susan L. Brooks-Wilson, Angela Agana, Luz Riby, Jacques Liu, Jianjun Adami, Hans-Olov Darabi, Hatef Hjalgrim, Henrik Low, Hui-Qi Humphreys, Keith Melbye, Mads Chang, Ellen T. Glimelius, Bengt Cozen, Wendy Davis, Scott Hartge, Patricia Morton, Lindsay M. Schenk, Maryjean Wang, Sophia S. Armstrong, Bruce Kricker, Anne Milliken, Sam Purdue, Mark P. Vajdic, Claire M. Boyle, Peter Lan, Qing Zahm, Shelia H. Zhang, Yawei Zheng, Tongzhang Becker, Nikolaus Benavente, Yolanda Boffetta, Paolo Brennan, Paul Butterbach, Katja Cocco, Pierluigi Foretova, Lenka Maynadié, Marc de Sanjosé, Silvia Staines, Anthony Spinelli, John J. Achenbach, Sara J. Call, Timothy G. Camp, Nicola J. Caporaso, Neil E. Cerhan, James R. Cunningham, Julie M. Goldin, Lynn R Hanson, Curtis A. Kay, Neil E. Lanasa, Mark C. Leis, Jose F. Marti, Gerald E. Rabe, Kari G. Rassenti, Laura Z. Spector, Logan G. Strom, Sara S. Vachon, Celine M. Weinberg, J. Brice Holly, Elizabeth A. Chanock, Stephen Smith, Martyn T. Bracci, Paige M. Skibola, Christine F. |
| author_facet | Conde, Lucia Halperin, Eran Akers, Nicholas K. Brown, Kevin M. Smedby, Karin E. Rothman, Nathaniel Nieters, Alexandra Slager, Susan L. Brooks-Wilson, Angela Agana, Luz Riby, Jacques Liu, Jianjun Adami, Hans-Olov Darabi, Hatef Hjalgrim, Henrik Low, Hui-Qi Humphreys, Keith Melbye, Mads Chang, Ellen T. Glimelius, Bengt Cozen, Wendy Davis, Scott Hartge, Patricia Morton, Lindsay M. Schenk, Maryjean Wang, Sophia S. Armstrong, Bruce Kricker, Anne Milliken, Sam Purdue, Mark P. Vajdic, Claire M. Boyle, Peter Lan, Qing Zahm, Shelia H. Zhang, Yawei Zheng, Tongzhang Becker, Nikolaus Benavente, Yolanda Boffetta, Paolo Brennan, Paul Butterbach, Katja Cocco, Pierluigi Foretova, Lenka Maynadié, Marc de Sanjosé, Silvia Staines, Anthony Spinelli, John J. Achenbach, Sara J. Call, Timothy G. Camp, Nicola J. Caporaso, Neil E. Cerhan, James R. Cunningham, Julie M. Goldin, Lynn R Hanson, Curtis A. Kay, Neil E. Lanasa, Mark C. Leis, Jose F. Marti, Gerald E. Rabe, Kari G. Rassenti, Laura Z. Spector, Logan G. Strom, Sara S. Vachon, Celine M. Weinberg, J. Brice Holly, Elizabeth A. Chanock, Stephen Smith, Martyn T. Bracci, Paige M. Skibola, Christine F. |
| author_sort | Conde, Lucia |
| collection | PubMed |
| description | To identify susceptibility loci for non-Hodgkin lymphoma (NHL) subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma (FL) in 1,465 FL cases/6,958 controls at 6p21.32 (rs10484561, rs7755224, r(2)=1.0; combined p-values=1.12×10(-29), 2.00×10(-19)), providing further support that MHC genetic variation influences FL susceptibility. Confirmatory evidence of a previously reported association was also found between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined p-value=4.24×10(-9)). |
| format | Text |
| id | pubmed-2913472 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29134722011-02-01 Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 Conde, Lucia Halperin, Eran Akers, Nicholas K. Brown, Kevin M. Smedby, Karin E. Rothman, Nathaniel Nieters, Alexandra Slager, Susan L. Brooks-Wilson, Angela Agana, Luz Riby, Jacques Liu, Jianjun Adami, Hans-Olov Darabi, Hatef Hjalgrim, Henrik Low, Hui-Qi Humphreys, Keith Melbye, Mads Chang, Ellen T. Glimelius, Bengt Cozen, Wendy Davis, Scott Hartge, Patricia Morton, Lindsay M. Schenk, Maryjean Wang, Sophia S. Armstrong, Bruce Kricker, Anne Milliken, Sam Purdue, Mark P. Vajdic, Claire M. Boyle, Peter Lan, Qing Zahm, Shelia H. Zhang, Yawei Zheng, Tongzhang Becker, Nikolaus Benavente, Yolanda Boffetta, Paolo Brennan, Paul Butterbach, Katja Cocco, Pierluigi Foretova, Lenka Maynadié, Marc de Sanjosé, Silvia Staines, Anthony Spinelli, John J. Achenbach, Sara J. Call, Timothy G. Camp, Nicola J. Caporaso, Neil E. Cerhan, James R. Cunningham, Julie M. Goldin, Lynn R Hanson, Curtis A. Kay, Neil E. Lanasa, Mark C. Leis, Jose F. Marti, Gerald E. Rabe, Kari G. Rassenti, Laura Z. Spector, Logan G. Strom, Sara S. Vachon, Celine M. Weinberg, J. Brice Holly, Elizabeth A. Chanock, Stephen Smith, Martyn T. Bracci, Paige M. Skibola, Christine F. Nat Genet Article To identify susceptibility loci for non-Hodgkin lymphoma (NHL) subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma (FL) in 1,465 FL cases/6,958 controls at 6p21.32 (rs10484561, rs7755224, r(2)=1.0; combined p-values=1.12×10(-29), 2.00×10(-19)), providing further support that MHC genetic variation influences FL susceptibility. Confirmatory evidence of a previously reported association was also found between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined p-value=4.24×10(-9)). 2010-07-18 2010-08 /pmc/articles/PMC2913472/ /pubmed/20639881 http://dx.doi.org/10.1038/ng.626 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Conde, Lucia Halperin, Eran Akers, Nicholas K. Brown, Kevin M. Smedby, Karin E. Rothman, Nathaniel Nieters, Alexandra Slager, Susan L. Brooks-Wilson, Angela Agana, Luz Riby, Jacques Liu, Jianjun Adami, Hans-Olov Darabi, Hatef Hjalgrim, Henrik Low, Hui-Qi Humphreys, Keith Melbye, Mads Chang, Ellen T. Glimelius, Bengt Cozen, Wendy Davis, Scott Hartge, Patricia Morton, Lindsay M. Schenk, Maryjean Wang, Sophia S. Armstrong, Bruce Kricker, Anne Milliken, Sam Purdue, Mark P. Vajdic, Claire M. Boyle, Peter Lan, Qing Zahm, Shelia H. Zhang, Yawei Zheng, Tongzhang Becker, Nikolaus Benavente, Yolanda Boffetta, Paolo Brennan, Paul Butterbach, Katja Cocco, Pierluigi Foretova, Lenka Maynadié, Marc de Sanjosé, Silvia Staines, Anthony Spinelli, John J. Achenbach, Sara J. Call, Timothy G. Camp, Nicola J. Caporaso, Neil E. Cerhan, James R. Cunningham, Julie M. Goldin, Lynn R Hanson, Curtis A. Kay, Neil E. Lanasa, Mark C. Leis, Jose F. Marti, Gerald E. Rabe, Kari G. Rassenti, Laura Z. Spector, Logan G. Strom, Sara S. Vachon, Celine M. Weinberg, J. Brice Holly, Elizabeth A. Chanock, Stephen Smith, Martyn T. Bracci, Paige M. Skibola, Christine F. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 |
| title | Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 |
| title_full | Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 |
| title_fullStr | Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 |
| title_full_unstemmed | Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 |
| title_short | Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 |
| title_sort | genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913472/ https://www.ncbi.nlm.nih.gov/pubmed/20639881 http://dx.doi.org/10.1038/ng.626 |
| work_keys_str_mv | AT condelucia genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT halperineran genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT akersnicholask genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT brownkevinm genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT smedbykarine genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT rothmannathaniel genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT nietersalexandra genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT slagersusanl genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT brookswilsonangela genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT aganaluz genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT ribyjacques genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT liujianjun genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT adamihansolov genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT darabihatef genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT hjalgrimhenrik genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT lowhuiqi genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT humphreyskeith genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT melbyemads genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT changellent genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT glimeliusbengt genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT cozenwendy genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT davisscott genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT hartgepatricia genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT mortonlindsaym genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT schenkmaryjean genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT wangsophias genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT armstrongbruce genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT krickeranne genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT millikensam genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT purduemarkp genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT vajdicclairem genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT boylepeter genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT lanqing genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT zahmsheliah genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT zhangyawei genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT zhengtongzhang genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT beckernikolaus genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT benaventeyolanda genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT boffettapaolo genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT brennanpaul genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT butterbachkatja genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT coccopierluigi genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT foretovalenka genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT maynadiemarc genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT desanjosesilvia genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT stainesanthony genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT spinellijohnj genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT achenbachsaraj genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT calltimothyg genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT campnicolaj genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT caporasoneile genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT cerhanjamesr genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT cunninghamjuliem genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT goldinlynnr genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT hansoncurtisa genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT kayneile genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT lanasamarkc genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT leisjosef genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT martigeralde genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT rabekarig genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT rassentilauraz genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT spectorlogang genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT stromsaras genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT vachoncelinem genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT weinbergjbrice genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT hollyelizabetha genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT chanockstephen genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT smithmartynt genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT braccipaigem genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 AT skibolachristinef genomewideassociationstudyoffollicularlymphomaidentifiesarisklocusat6p2132 |