Efficacy and tolerability of injectable sodium valproate in patients with mania

BACKGROUND: Sodium valproate is among the newer mood stabilizers and is also an anticonvulsant. AIM: To assess the effect of intravenous sodium valproate in patients with acute manic episodes of bipolar disorder. METHODS: A 1-week open trial was conducted in the year 2004–2005 at the emergency ward...

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Detalles Bibliográficos
Autores principales: Solanki, R. K., Singh, Paramjeet, Khandelwal, Renu, Midha, Aarti
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2006
Materias:
Brief Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913561/
https://www.ncbi.nlm.nih.gov/pubmed/20703399
http://dx.doi.org/10.4103/0019-5545.31603
Descripción
Sumario:BACKGROUND: Sodium valproate is among the newer mood stabilizers and is also an anticonvulsant. AIM: To assess the effect of intravenous sodium valproate in patients with acute manic episodes of bipolar disorder. METHODS: A 1-week open trial was conducted in the year 2004–2005 at the emergency ward of the Psychiatric Centre, SMS Medical College, Jaipur, in which 30 patients participated. CONCLUSION: Substantial improvement was seen. No major side-effects were noted except marginal elevation of the SGOT and SGPT. The findings suggest that injectable sodium valproate is a safe and effective mood stabilizer for patients with mania.

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