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Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains

Experimental studies about Leishmania resistance to metal and antifolates have pointed out that gene amplification is one of the main mechanisms of drug detoxification. Amplified genes code for adenosine triphosphate-dependent transporters (multidrug resistance and P-glycoproteins P), enzymes involv...

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Detalles Bibliográficos
Autores principales:	Mary, C., Faraut, F., Deniau, M., Dereure, J., Aoun, K., Ranque, S., Piarroux, R.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913627/ https://www.ncbi.nlm.nih.gov/pubmed/20706666 http://dx.doi.org/10.1155/2010/819060

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