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Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye
Purpose. Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported to have anti-angiogenic effects. The purpose of this study is to investigat...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913841/ https://www.ncbi.nlm.nih.gov/pubmed/20706646 http://dx.doi.org/10.1155/2010/206837 |
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author | Honda, Shigeru Nagai, Takayuki Kondo, Naoshi Fukuda, Masahide Kusuhara, Sentaro Tsukahara, Yasutomo Negi, Akira |
author_facet | Honda, Shigeru Nagai, Takayuki Kondo, Naoshi Fukuda, Masahide Kusuhara, Sentaro Tsukahara, Yasutomo Negi, Akira |
author_sort | Honda, Shigeru |
collection | PubMed |
description | Purpose. Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported to have anti-angiogenic effects. The purpose of this study is to investigate the therapeutic effects of oral bisphosphonates for CNV in humans. Methods. Thirty-six consecutive cases with CNV due to AMD or PM who declined anti-VEGF therapy were recruited. The patients were prescribed 5 mg of oral alendronates daily for 6 months. The best-corrected visual-acuity (BCVA), the lesion size in fundus photographs and fluorescein angiography, foveal thickness and total macular volume in optical coherence tomography were compared between pre- and post-treatment. Results. The mean BCVA of the patients was significantly improved after a months with the treatment in the AMD group. In the PM group, the mean BCVA was maintained up to 6 months with the treatment. The mean lesion size was significantly decreased by 3 months in both groups. The averages of foveal thickness and total macular volume were significantly reduced after 1 month of treatment in the AMD group.Conclusions. Oral bisphosphonate should be further investigated as a possible therapeutic and preventive drug for CNV due to AMD and PM. |
format | Text |
id | pubmed-2913841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29138412010-08-12 Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye Honda, Shigeru Nagai, Takayuki Kondo, Naoshi Fukuda, Masahide Kusuhara, Sentaro Tsukahara, Yasutomo Negi, Akira J Ophthalmol Clinical Study Purpose. Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported to have anti-angiogenic effects. The purpose of this study is to investigate the therapeutic effects of oral bisphosphonates for CNV in humans. Methods. Thirty-six consecutive cases with CNV due to AMD or PM who declined anti-VEGF therapy were recruited. The patients were prescribed 5 mg of oral alendronates daily for 6 months. The best-corrected visual-acuity (BCVA), the lesion size in fundus photographs and fluorescein angiography, foveal thickness and total macular volume in optical coherence tomography were compared between pre- and post-treatment. Results. The mean BCVA of the patients was significantly improved after a months with the treatment in the AMD group. In the PM group, the mean BCVA was maintained up to 6 months with the treatment. The mean lesion size was significantly decreased by 3 months in both groups. The averages of foveal thickness and total macular volume were significantly reduced after 1 month of treatment in the AMD group.Conclusions. Oral bisphosphonate should be further investigated as a possible therapeutic and preventive drug for CNV due to AMD and PM. Hindawi Publishing Corporation 2010 2010-07-25 /pmc/articles/PMC2913841/ /pubmed/20706646 http://dx.doi.org/10.1155/2010/206837 Text en Copyright © 2010 Shigeru Honda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Honda, Shigeru Nagai, Takayuki Kondo, Naoshi Fukuda, Masahide Kusuhara, Sentaro Tsukahara, Yasutomo Negi, Akira Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
title | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
title_full | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
title_fullStr | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
title_full_unstemmed | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
title_short | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
title_sort | therapeutic effect of oral bisphosphonates on choroidal neovascularization in the human eye |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913841/ https://www.ncbi.nlm.nih.gov/pubmed/20706646 http://dx.doi.org/10.1155/2010/206837 |
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