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Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01,...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913856/ https://www.ncbi.nlm.nih.gov/pubmed/20706659 http://dx.doi.org/10.1155/2010/951210 |
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author | Zhou, Ling-ling Wei, Wei Si, Jun-feng Yuan, Dong-ping |
author_facet | Zhou, Ling-ling Wei, Wei Si, Jun-feng Yuan, Dong-ping |
author_sort | Zhou, Ling-ling |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances. |
format | Text |
id | pubmed-2913856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29138562010-08-12 Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice Zhou, Ling-ling Wei, Wei Si, Jun-feng Yuan, Dong-ping Mediators Inflamm Research Article Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances. Hindawi Publishing Corporation 2010 2010-07-20 /pmc/articles/PMC2913856/ /pubmed/20706659 http://dx.doi.org/10.1155/2010/951210 Text en Copyright © 2010 Ling-ling Zhou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Ling-ling Wei, Wei Si, Jun-feng Yuan, Dong-ping Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
title | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
title_full | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
title_fullStr | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
title_full_unstemmed | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
title_short | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
title_sort | regulatory effect of melatonin on cytokine disturbances in the pristane-induced lupus mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913856/ https://www.ncbi.nlm.nih.gov/pubmed/20706659 http://dx.doi.org/10.1155/2010/951210 |
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