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Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice

Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01,...

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Detalles Bibliográficos
Autores principales: Zhou, Ling-ling, Wei, Wei, Si, Jun-feng, Yuan, Dong-ping
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913856/
https://www.ncbi.nlm.nih.gov/pubmed/20706659
http://dx.doi.org/10.1155/2010/951210
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author Zhou, Ling-ling
Wei, Wei
Si, Jun-feng
Yuan, Dong-ping
author_facet Zhou, Ling-ling
Wei, Wei
Si, Jun-feng
Yuan, Dong-ping
author_sort Zhou, Ling-ling
collection PubMed
description Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.
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spelling pubmed-29138562010-08-12 Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice Zhou, Ling-ling Wei, Wei Si, Jun-feng Yuan, Dong-ping Mediators Inflamm Research Article Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances. Hindawi Publishing Corporation 2010 2010-07-20 /pmc/articles/PMC2913856/ /pubmed/20706659 http://dx.doi.org/10.1155/2010/951210 Text en Copyright © 2010 Ling-ling Zhou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Ling-ling
Wei, Wei
Si, Jun-feng
Yuan, Dong-ping
Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
title Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
title_full Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
title_fullStr Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
title_full_unstemmed Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
title_short Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
title_sort regulatory effect of melatonin on cytokine disturbances in the pristane-induced lupus mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913856/
https://www.ncbi.nlm.nih.gov/pubmed/20706659
http://dx.doi.org/10.1155/2010/951210
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