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The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth

Preterm birth (PTB) is clinically defined as any delivery which occurs before the completion of 37 weeks of gestation, and is currently the most important problem in obstetrics. In the United States, PTB accounts for 12-13% of all live births, and, with the exception of fetuses suffering from anomal...

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Detalles Bibliográficos
Autores principales: Olgun, Nicole S., Reznik, Sandra E.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913859/
https://www.ncbi.nlm.nih.gov/pubmed/20706662
http://dx.doi.org/10.1155/2010/657039
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author Olgun, Nicole S.
Reznik, Sandra E.
author_facet Olgun, Nicole S.
Reznik, Sandra E.
author_sort Olgun, Nicole S.
collection PubMed
description Preterm birth (PTB) is clinically defined as any delivery which occurs before the completion of 37 weeks of gestation, and is currently the most important problem in obstetrics. In the United States, PTB accounts for 12-13% of all live births, and, with the exception of fetuses suffering from anomalies, is the primary cause of perinatal mortality. While the risk factors for PTB are numerous, the single most common cause is intrauterine infection. As there is currently no FDA-approved therapy for infection-associated PTB, understanding the pathogenesis of preterm labor (PTL) and delivery should be given high priority. The matrix metalloproteinases (MMPs) are a family of enzymes that have been implicated in normal parturition as well as infection-triggered rupture of membranes and preterm birth. Several lines of evidence also suggest a role for endothelin-1 (ET-1) in infection-associated preterm delivery. This paper focuses on the evidence that the MMPs and ET-1 act in the same molecular pathway in preterm birth.
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spelling pubmed-29138592010-08-12 The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth Olgun, Nicole S. Reznik, Sandra E. Obstet Gynecol Int Review Article Preterm birth (PTB) is clinically defined as any delivery which occurs before the completion of 37 weeks of gestation, and is currently the most important problem in obstetrics. In the United States, PTB accounts for 12-13% of all live births, and, with the exception of fetuses suffering from anomalies, is the primary cause of perinatal mortality. While the risk factors for PTB are numerous, the single most common cause is intrauterine infection. As there is currently no FDA-approved therapy for infection-associated PTB, understanding the pathogenesis of preterm labor (PTL) and delivery should be given high priority. The matrix metalloproteinases (MMPs) are a family of enzymes that have been implicated in normal parturition as well as infection-triggered rupture of membranes and preterm birth. Several lines of evidence also suggest a role for endothelin-1 (ET-1) in infection-associated preterm delivery. This paper focuses on the evidence that the MMPs and ET-1 act in the same molecular pathway in preterm birth. Hindawi Publishing Corporation 2010 2010-07-26 /pmc/articles/PMC2913859/ /pubmed/20706662 http://dx.doi.org/10.1155/2010/657039 Text en Copyright © 2010 N. S. Olgun and S. E. Reznik. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Olgun, Nicole S.
Reznik, Sandra E.
The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
title The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
title_full The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
title_fullStr The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
title_full_unstemmed The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
title_short The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
title_sort matrix metalloproteases and endothelin-1 in infection-associated preterm birth
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913859/
https://www.ncbi.nlm.nih.gov/pubmed/20706662
http://dx.doi.org/10.1155/2010/657039
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