TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells

BACKGROUND: The homeobox gene TLX1 (for T-cell leukemia homeobox 1, previously known as HOX11) is inappropriately expressed in a major subgroup of T cell acute lymphoblastic leukemia (T-ALL) where it is strongly associated with activating NOTCH1 mutations. Despite the recognition that these genetic...

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Detalles Bibliográficos
Autores principales: Riz, Irene, Hawley, Teresa S, Luu, Truong V, Lee, Norman H, Hawley, Robert G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913983/
https://www.ncbi.nlm.nih.gov/pubmed/20618946
http://dx.doi.org/10.1186/1476-4598-9-181

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