Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate

In the crystal structure of the title compound, C(22)H(24)FN(3)O(4), the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)°. The cyclo­hexyl ring...

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Detalles Bibliográficos
Autores principales: Sun, Yong, Zeng, Guo-Ping, Hu, Yang-Gen
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2007
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915357/
https://www.ncbi.nlm.nih.gov/pubmed/21200874
http://dx.doi.org/10.1107/S1600536807066780
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author Sun, Yong
Zeng, Guo-Ping
Hu, Yang-Gen
author_facet Sun, Yong
Zeng, Guo-Ping
Hu, Yang-Gen
author_sort Sun, Yong
collection PubMed
description In the crystal structure of the title compound, C(22)H(24)FN(3)O(4), the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)°. The cyclo­hexyl ring shows a distorted chair conformation. The mol­ecular structure is stabilized by intra­molecular C—H⋯O and C—H⋯N hydrogen-bonding inter­actions. The crystal packing is mainly stabilized by C—H⋯π hydrogen-bond inter­actions. Further stability is provided by C—F⋯π and C—O⋯π stacking inter­actions.
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spelling pubmed-29153572010-12-30 Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate Sun, Yong Zeng, Guo-Ping Hu, Yang-Gen Acta Crystallogr Sect E Struct Rep Online Organic Papers In the crystal structure of the title compound, C(22)H(24)FN(3)O(4), the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)°. The cyclo­hexyl ring shows a distorted chair conformation. The mol­ecular structure is stabilized by intra­molecular C—H⋯O and C—H⋯N hydrogen-bonding inter­actions. The crystal packing is mainly stabilized by C—H⋯π hydrogen-bond inter­actions. Further stability is provided by C—F⋯π and C—O⋯π stacking inter­actions. International Union of Crystallography 2007-12-21 /pmc/articles/PMC2915357/ /pubmed/21200874 http://dx.doi.org/10.1107/S1600536807066780 Text en © Sun et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Sun, Yong
Zeng, Guo-Ping
Hu, Yang-Gen
Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate
title Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate
title_full Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate
title_fullStr Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate
title_full_unstemmed Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate
title_short Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate
title_sort ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915357/
https://www.ncbi.nlm.nih.gov/pubmed/21200874
http://dx.doi.org/10.1107/S1600536807066780
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AT zengguoping ethyl34fluorophenyl6methyl4oxo21cyclohexylamino34dihydrofuro23dpyrimidine5carboxylate
AT huyanggen ethyl34fluorophenyl6methyl4oxo21cyclohexylamino34dihydrofuro23dpyrimidine5carboxylate

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