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Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and Its Possible Relation with the 5-Fluorouracil Drug Response

Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and it is the target for the 5-Fluorouracil (5-FU) activity. Barbour et al. showed that variant structural forms of TS in tumour cell lines confer resistance to fluoropyrimidines. We planned to perform the whole TS gene structure by mea...

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Detalles Bibliográficos
Autores principales:	Calascibetta, A., Contino, Flavia, Feo, S., Gulotta, G., Cajozzo, M., Antona, A., Sanguedolce, G., Sanguedolce, R.
Formato:	Texto
Lenguaje:	English
Publicado:	SAGE-Hindawi Access to Research 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915790/ https://www.ncbi.nlm.nih.gov/pubmed/20725619 http://dx.doi.org/10.4061/2010/306754

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