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Electroretinographic findings in transplant chorioretinopathy
AIM: Transplant chorioretinopathy is a rare complication following solid organ or bone marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG) results in patients with this condition. METHODS: Patients who presented with bilateral vision loss followi...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915864/ https://www.ncbi.nlm.nih.gov/pubmed/20689794 |
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author | Chan-Kai, Brian T Yeh, Steven Weleber, Richard G Francis, Peter J Adamus, Grazyna Witherspoon, S Robert Lauer, Andreas K |
author_facet | Chan-Kai, Brian T Yeh, Steven Weleber, Richard G Francis, Peter J Adamus, Grazyna Witherspoon, S Robert Lauer, Andreas K |
author_sort | Chan-Kai, Brian T |
collection | PubMed |
description | AIM: Transplant chorioretinopathy is a rare complication following solid organ or bone marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG) results in patients with this condition. METHODS: Patients who presented with bilateral vision loss following bone marrow or solid organ transplantation were identified. A complete ophthalmologic examination, fundus photography, and fluorescein angiography (FA) were performed. Full-field ERG was obtained in all patients and a multifocal ERG (mfERG) was obtained in two patients. RESULTS: Four patients were identified. All patients had bilateral vision loss and displayed a characteristic pattern of mottled hyperfluorescence on FA. Three patients developed progressive vision loss ranging from 20/60 to hand motions whereas one retained 20/40 vision. All patients exhibited moderate to severe cone dysfunction, while the degree of rod abnormalities was varied. Two patients with severe cone dysfunction showed mild clinical changes initially, but later developed progressive vision loss and chorioretinal atrophy. CONCLUSION: Transplant chorioretinopathy patients undergoing ERG testing show cone dysfunction with a variable degree of rod dysfunction. ERG abnormalities preceded the visual acuity and clinical changes in two patients, suggesting that ERG may be a helpful predictor of the clinical course in this rare disease. |
format | Text |
id | pubmed-2915864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-29158642010-08-04 Electroretinographic findings in transplant chorioretinopathy Chan-Kai, Brian T Yeh, Steven Weleber, Richard G Francis, Peter J Adamus, Grazyna Witherspoon, S Robert Lauer, Andreas K Clin Ophthalmol Case Series AIM: Transplant chorioretinopathy is a rare complication following solid organ or bone marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG) results in patients with this condition. METHODS: Patients who presented with bilateral vision loss following bone marrow or solid organ transplantation were identified. A complete ophthalmologic examination, fundus photography, and fluorescein angiography (FA) were performed. Full-field ERG was obtained in all patients and a multifocal ERG (mfERG) was obtained in two patients. RESULTS: Four patients were identified. All patients had bilateral vision loss and displayed a characteristic pattern of mottled hyperfluorescence on FA. Three patients developed progressive vision loss ranging from 20/60 to hand motions whereas one retained 20/40 vision. All patients exhibited moderate to severe cone dysfunction, while the degree of rod abnormalities was varied. Two patients with severe cone dysfunction showed mild clinical changes initially, but later developed progressive vision loss and chorioretinal atrophy. CONCLUSION: Transplant chorioretinopathy patients undergoing ERG testing show cone dysfunction with a variable degree of rod dysfunction. ERG abnormalities preceded the visual acuity and clinical changes in two patients, suggesting that ERG may be a helpful predictor of the clinical course in this rare disease. Dove Medical Press 2010 2010-07-30 /pmc/articles/PMC2915864/ /pubmed/20689794 Text en © 2010 Chan-Kai et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Case Series Chan-Kai, Brian T Yeh, Steven Weleber, Richard G Francis, Peter J Adamus, Grazyna Witherspoon, S Robert Lauer, Andreas K Electroretinographic findings in transplant chorioretinopathy |
title | Electroretinographic findings in transplant chorioretinopathy |
title_full | Electroretinographic findings in transplant chorioretinopathy |
title_fullStr | Electroretinographic findings in transplant chorioretinopathy |
title_full_unstemmed | Electroretinographic findings in transplant chorioretinopathy |
title_short | Electroretinographic findings in transplant chorioretinopathy |
title_sort | electroretinographic findings in transplant chorioretinopathy |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915864/ https://www.ncbi.nlm.nih.gov/pubmed/20689794 |
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