Calpain 3 Is a Rapid-Action, Unidirectional Proteolytic Switch Central to Muscle Remodeling

Calpain 3 (CAPN3) is a cysteine protease that when mutated causes Limb Girdle Muscular Dystrophy 2A. It is thereby the only described Calpain family member that genetically causes a disease. Due to its inherent instability little is known of its substrates or its mechanism of activity and pathogenic...

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Detalles Bibliográficos
Autores principales: de Morrée, Antoine, Lutje Hulsik, David, Impagliazzo, Antonietta, van Haagen, Herman H. H. B. M., de Galan, Paula, van Remoortere, Alexandra, 't Hoen, Peter A. C., van Ommen, GertJan B., Frants, Rune R., van der Maarel, Silvère M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915920/
https://www.ncbi.nlm.nih.gov/pubmed/20694146
http://dx.doi.org/10.1371/journal.pone.0011940

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