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A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men

We conducted a two-stage genome-wide association study to identify common genetic variation altering risk of the metabolic syndrome and related phenotypes in Indian Asian men, who have a high prevalence of these conditions. In Stage 1, approximately 317,000 single nucleotide polymorphisms were genot...

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Detalles Bibliográficos
Autores principales: Zabaneh, Delilah, Balding, David J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915922/
https://www.ncbi.nlm.nih.gov/pubmed/20694148
http://dx.doi.org/10.1371/journal.pone.0011961
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author Zabaneh, Delilah
Balding, David J.
author_facet Zabaneh, Delilah
Balding, David J.
author_sort Zabaneh, Delilah
collection PubMed
description We conducted a two-stage genome-wide association study to identify common genetic variation altering risk of the metabolic syndrome and related phenotypes in Indian Asian men, who have a high prevalence of these conditions. In Stage 1, approximately 317,000 single nucleotide polymorphisms were genotyped in 2700 individuals, from which 1500 SNPs were selected to be genotyped in a further 2300 individuals. Selection for inclusion in Stage 1 was based on four metabolic syndrome component traits: HDL-cholesterol, plasma glucose and Type 2 diabetes, abdominal obesity measured by waist to hip ratio, and diastolic blood pressure. Association was tested with these four traits and a composite metabolic syndrome phenotype. Four SNPs reaching significance level p<5×10(−7) and with posterior probability of association >0.8 were found in genes CETP and LPL, associated with HDL-cholesterol. These associations have already been reported in Indian Asians and in Europeans. Five additional loci harboured SNPs significant at p<10(−6) and posterior probability >0.5 for HDL-cholesterol, type 2 diabetes or diastolic blood pressure. Our results suggest that the primary genetic determinants of metabolic syndrome are the same in Indian Asians as in other populations, despite the higher prevalence. Further, we found little evidence of a common genetic basis for metabolic syndrome traits in our sample of Indian Asian men.
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spelling pubmed-29159222010-08-05 A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men Zabaneh, Delilah Balding, David J. PLoS One Research Article We conducted a two-stage genome-wide association study to identify common genetic variation altering risk of the metabolic syndrome and related phenotypes in Indian Asian men, who have a high prevalence of these conditions. In Stage 1, approximately 317,000 single nucleotide polymorphisms were genotyped in 2700 individuals, from which 1500 SNPs were selected to be genotyped in a further 2300 individuals. Selection for inclusion in Stage 1 was based on four metabolic syndrome component traits: HDL-cholesterol, plasma glucose and Type 2 diabetes, abdominal obesity measured by waist to hip ratio, and diastolic blood pressure. Association was tested with these four traits and a composite metabolic syndrome phenotype. Four SNPs reaching significance level p<5×10(−7) and with posterior probability of association >0.8 were found in genes CETP and LPL, associated with HDL-cholesterol. These associations have already been reported in Indian Asians and in Europeans. Five additional loci harboured SNPs significant at p<10(−6) and posterior probability >0.5 for HDL-cholesterol, type 2 diabetes or diastolic blood pressure. Our results suggest that the primary genetic determinants of metabolic syndrome are the same in Indian Asians as in other populations, despite the higher prevalence. Further, we found little evidence of a common genetic basis for metabolic syndrome traits in our sample of Indian Asian men. Public Library of Science 2010-08-04 /pmc/articles/PMC2915922/ /pubmed/20694148 http://dx.doi.org/10.1371/journal.pone.0011961 Text en Zabaneh, Balding. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zabaneh, Delilah
Balding, David J.
A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
title A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
title_full A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
title_fullStr A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
title_full_unstemmed A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
title_short A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
title_sort genome-wide association study of the metabolic syndrome in indian asian men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915922/
https://www.ncbi.nlm.nih.gov/pubmed/20694148
http://dx.doi.org/10.1371/journal.pone.0011961
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