Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

BACKGROUND: Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of several biological processes, including the stress resistance, metabolism, cell cycle, apoptosis and DNA repair. The objectives of this study we...

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Detalles Bibliográficos
Autores principales: Roy, Sanjit K, Srivastava, Rakesh K, Shankar, Sharmila
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915986/
https://www.ncbi.nlm.nih.gov/pubmed/20642839
http://dx.doi.org/10.1186/1750-2187-5-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915986/
https://www.ncbi.nlm.nih.gov/pubmed/20642839
http://dx.doi.org/10.1186/1750-2187-5-10

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