Aggregated Recombinant Human Interferon Beta Induces Antibodies but No Memory in Immune-Tolerant Transgenic Mice

PURPOSE: To study the influence of protein aggregation on the immunogenicity of recombinant human interferon beta (rhIFNβ) in wild-type mice and transgenic, immune-tolerant mice, and to evaluate the induction of immunological memory. METHODS: RhIFNβ-1b and three rhIFNβ-1a preparations with different...

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Detalles Bibliográficos
Autores principales: van Beers, Miranda M. C., Sauerborn, Melody, Gilli, Francesca, Brinks, Vera, Schellekens, Huub, Jiskoot, Wim
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916121/
https://www.ncbi.nlm.nih.gov/pubmed/20499141
http://dx.doi.org/10.1007/s11095-010-0172-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916121/
https://www.ncbi.nlm.nih.gov/pubmed/20499141
http://dx.doi.org/10.1007/s11095-010-0172-0

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