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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

Intracellular pathogens and endogenous danger signals in the cytosol engage NOD-like receptors (NLRs), which assemble inflammasome complexes to activate caspase-1 and promote the release of proinflammatory cytokines IL-1β and IL-18. However, the NLRs that respond to microbial pathogens in vivo are p...

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Detalles Bibliográficos
Autores principales:	Broz, Petr, Newton, Kim, Lamkanfi, Mohamed, Mariathasan, Sanjeev, Dixit, Vishva M., Monack, Denise M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916133/ https://www.ncbi.nlm.nih.gov/pubmed/20603313 http://dx.doi.org/10.1084/jem.20100257

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