G(αq)-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity

Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the G(αq) subunit of trimeric G proteins (Gnaq(−/−) mice) have an intrinsic survival advantage over normal B cells, even in the absence of BAFF. Gnaq(−/−) B cells develop no...

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Detalles Bibliográficos
Autores principales: Misra, Ravi S., Shi, Guixiu, Moreno-Garcia, Miguel E., Thankappan, Anil, Tighe, Michael, Mousseau, Betty, Kusser, Kim, Becker-Herman, Shirly, Hudkins, Kelly L., Dunn, Robert, Kehry, Marilyn R., Migone, Thi-Sau, Marshak-Rothstein, Ann, Simon, Melvin, Randall, Troy D., Alpers, Charles E., Liggitt, Denny, Rawlings, David J., Lund, Frances E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916136/
https://www.ncbi.nlm.nih.gov/pubmed/20624888
http://dx.doi.org/10.1084/jem.20092735

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