An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer

Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either d...

Descripción completa

Detalles Bibliográficos
Autores principales: Asquith, Mark, Powrie, Fiona
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916138/
https://www.ncbi.nlm.nih.gov/pubmed/20679404
http://dx.doi.org/10.1084/jem.20101330
_version_ 1782185001760063488
author Asquith, Mark
Powrie, Fiona
author_facet Asquith, Mark
Powrie, Fiona
author_sort Asquith, Mark
collection PubMed
description Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either diminished or exacerbated innate immune signaling may trigger the breakdown of intestinal homeostasis, leading to IBD and colitis-associated cancer (CAC). This dichotomy may reflect divergent functional roles for immune sensing in intestinal epithelial cells and leukocytes, which may vary with distinct disease mechanisms.
format Text
id pubmed-2916138
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-29161382011-02-02 An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer Asquith, Mark Powrie, Fiona J Exp Med Minireview Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either diminished or exacerbated innate immune signaling may trigger the breakdown of intestinal homeostasis, leading to IBD and colitis-associated cancer (CAC). This dichotomy may reflect divergent functional roles for immune sensing in intestinal epithelial cells and leukocytes, which may vary with distinct disease mechanisms. The Rockefeller University Press 2010-08-02 /pmc/articles/PMC2916138/ /pubmed/20679404 http://dx.doi.org/10.1084/jem.20101330 Text en © 2010 Asquith and Powrie This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Minireview
Asquith, Mark
Powrie, Fiona
An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer
title An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer
title_full An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer
title_fullStr An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer
title_full_unstemmed An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer
title_short An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer
title_sort innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916138/
https://www.ncbi.nlm.nih.gov/pubmed/20679404
http://dx.doi.org/10.1084/jem.20101330
work_keys_str_mv AT asquithmark aninnatelydangerousbalancingactintestinalhomeostasisinflammationandcolitisassociatedcancer
AT powriefiona aninnatelydangerousbalancingactintestinalhomeostasisinflammationandcolitisassociatedcancer
AT asquithmark innatelydangerousbalancingactintestinalhomeostasisinflammationandcolitisassociatedcancer
AT powriefiona innatelydangerousbalancingactintestinalhomeostasisinflammationandcolitisassociatedcancer

Ejemplares similares