Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits

Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [(18)F]fallypride PET and BOLD fMRI, we show that impulsive-antisocial psychopathic traits selectively predict nucleus accumbens dopamine release and reward anticipation-related neural activity in response to p...

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Detalles Bibliográficos
Autores principales: Buckholtz, Joshua W., Treadway, Michael T., Cowan, Ronald L., Woodward, Neil D., Benning, Stephen D., Li, Rui, Ansari, M. Sib, Baldwin, Ronald M., Schwartzman, Ashley N., Shelby, Evan S., Smith, Clarence E., Cole, David, Kessler, Robert M., Zald, David H.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916168/
https://www.ncbi.nlm.nih.gov/pubmed/20228805
http://dx.doi.org/10.1038/nn.2510
Descripción
Sumario:Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [(18)F]fallypride PET and BOLD fMRI, we show that impulsive-antisocial psychopathic traits selectively predict nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyperreactivity of the dopaminergic reward system may comprise a neural substrate for impulsivity, antisocial behavior and substance abuse in psychopathy.

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