Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits

Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [(18)F]fallypride PET and BOLD fMRI, we show that impulsive-antisocial psychopathic traits selectively predict nucleus accumbens dopamine release and reward anticipation-related neural activity in response to p...

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Autores principales: Buckholtz, Joshua W., Treadway, Michael T., Cowan, Ronald L., Woodward, Neil D., Benning, Stephen D., Li, Rui, Ansari, M. Sib, Baldwin, Ronald M., Schwartzman, Ashley N., Shelby, Evan S., Smith, Clarence E., Cole, David, Kessler, Robert M., Zald, David H.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916168/
https://www.ncbi.nlm.nih.gov/pubmed/20228805
http://dx.doi.org/10.1038/nn.2510
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author Buckholtz, Joshua W.
Treadway, Michael T.
Cowan, Ronald L.
Woodward, Neil D.
Benning, Stephen D.
Li, Rui
Ansari, M. Sib
Baldwin, Ronald M.
Schwartzman, Ashley N.
Shelby, Evan S.
Smith, Clarence E.
Cole, David
Kessler, Robert M.
Zald, David H.
author_facet Buckholtz, Joshua W.
Treadway, Michael T.
Cowan, Ronald L.
Woodward, Neil D.
Benning, Stephen D.
Li, Rui
Ansari, M. Sib
Baldwin, Ronald M.
Schwartzman, Ashley N.
Shelby, Evan S.
Smith, Clarence E.
Cole, David
Kessler, Robert M.
Zald, David H.
author_sort Buckholtz, Joshua W.
collection PubMed
description Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [(18)F]fallypride PET and BOLD fMRI, we show that impulsive-antisocial psychopathic traits selectively predict nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyperreactivity of the dopaminergic reward system may comprise a neural substrate for impulsivity, antisocial behavior and substance abuse in psychopathy.
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spelling pubmed-29161682010-10-01 Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits Buckholtz, Joshua W. Treadway, Michael T. Cowan, Ronald L. Woodward, Neil D. Benning, Stephen D. Li, Rui Ansari, M. Sib Baldwin, Ronald M. Schwartzman, Ashley N. Shelby, Evan S. Smith, Clarence E. Cole, David Kessler, Robert M. Zald, David H. Nat Neurosci Article Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [(18)F]fallypride PET and BOLD fMRI, we show that impulsive-antisocial psychopathic traits selectively predict nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyperreactivity of the dopaminergic reward system may comprise a neural substrate for impulsivity, antisocial behavior and substance abuse in psychopathy. 2010-03-14 2010-04 /pmc/articles/PMC2916168/ /pubmed/20228805 http://dx.doi.org/10.1038/nn.2510 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Buckholtz, Joshua W.
Treadway, Michael T.
Cowan, Ronald L.
Woodward, Neil D.
Benning, Stephen D.
Li, Rui
Ansari, M. Sib
Baldwin, Ronald M.
Schwartzman, Ashley N.
Shelby, Evan S.
Smith, Clarence E.
Cole, David
Kessler, Robert M.
Zald, David H.
Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits
title Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits
title_full Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits
title_fullStr Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits
title_full_unstemmed Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits
title_short Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits
title_sort mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916168/
https://www.ncbi.nlm.nih.gov/pubmed/20228805
http://dx.doi.org/10.1038/nn.2510
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