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The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression†,‡

[Image: see text] The mixed lineage leukemia (MLL) gene plays a critical role in epigenetic regulation of gene expression and is a frequent target of chromosomal translocations leading to leukemia. MLL plant homeodomain 3 (PHD3) is lost in all MLL translocation products, and reinsertion of PHD3 into...

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Detalles Bibliográficos
Autores principales:	Park, Sangho, Osmers, Ute, Raman, Gayathree, Schwantes, Rebecca H., Diaz, Manuel O., Bushweller, John H.
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2010
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916634/ https://www.ncbi.nlm.nih.gov/pubmed/20677832 http://dx.doi.org/10.1021/bi1009387

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