H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output

H-Ras is a binary switch that is activated by multiple co-factors and triggers several key cellular pathways one of which is MAPK. The specificity and magnitude of downstream activation is achieved by the spatio-temporal organization of the active H-Ras in the plasma membrane. Upon activation, the G...

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Detalles Bibliográficos
Autores principales: Rotblat, Barak, Belanis, Liron, Liang, Hong, Haklai, Roni, Elad-Zefadia, Galit, Hancock, John F., Kloog, Yoel, Plowman, Sarah J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916832/
https://www.ncbi.nlm.nih.gov/pubmed/20700538
http://dx.doi.org/10.1371/journal.pone.0011991

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