Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes. In particular, association with the nonsynonymous...

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Autores principales: Saccone, Nancy L., Culverhouse, Robert C., Schwantes-An, Tae-Hwi, Cannon, Dale S., Chen, Xiangning, Cichon, Sven, Giegling, Ina, Han, Shizhong, Han, Younghun, Keskitalo-Vuokko, Kaisu, Kong, Xiangyang, Landi, Maria Teresa, Ma, Jennie Z., Short, Susan E., Stephens, Sarah H., Stevens, Victoria L., Sun, Lingwei, Wang, Yufei, Wenzlaff, Angela S., Aggen, Steven H., Breslau, Naomi, Broderick, Peter, Chatterjee, Nilanjan, Chen, Jingchun, Heath, Andrew C., Heliövaara, Markku, Hoft, Nicole R., Hunter, David J., Jensen, Majken K., Martin, Nicholas G., Montgomery, Grant W., Niu, Tianhua, Payne, Thomas J., Peltonen, Leena, Pergadia, Michele L., Rice, John P., Sherva, Richard, Spitz, Margaret R., Sun, Juzhong, Wang, Jen C., Weiss, Robert B., Wheeler, William, Witt, Stephanie H., Yang, Bao-Zhu, Caporaso, Neil E., Ehringer, Marissa A., Eisen, Tim, Gapstur, Susan M., Gelernter, Joel, Houlston, Richard, Kaprio, Jaakko, Kendler, Kenneth S., Kraft, Peter, Leppert, Mark F., Li, Ming D., Madden, Pamela A. F., Nöthen, Markus M., Pillai, Sreekumar, Rietschel, Marcella, Rujescu, Dan, Schwartz, Ann, Amos, Christopher I., Bierut, Laura J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916847/
https://www.ncbi.nlm.nih.gov/pubmed/20700436
http://dx.doi.org/10.1371/journal.pgen.1001053

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