Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

Saccharomyces cerevisiae Rad9 is required for an effective DNA damage response throughout the cell cycle. Assembly of Rad9 on chromatin after DNA damage is promoted by histone modifications that create docking sites for Rad9 recruitment, allowing checkpoint activation. Rad53 phosphorylation is also...

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Detalles Bibliográficos
Autores principales: Granata, Magda, Lazzaro, Federico, Novarina, Daniele, Panigada, Davide, Puddu, Fabio, Abreu, Carla Manuela, Kumar, Ramesh, Grenon, Muriel, Lowndes, Noel F., Plevani, Paolo, Muzi-Falconi, Marco
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916856/
https://www.ncbi.nlm.nih.gov/pubmed/20700441
http://dx.doi.org/10.1371/journal.pgen.1001047

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