RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

Caenorhabditis elegans SKN-1 (ortholog of mammalian Nrf1/2/3) is critical for oxidative stress resistance and promotes longevity under reduced insulin/IGF-1–like signaling (IIS), dietary restriction (DR), and normal conditions. SKN-1 inducibly activates genes involved in detoxification, protein home...

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Detalles Bibliográficos
Autores principales: Wang, Jinling, Robida-Stubbs, Stacey, Tullet, Jennifer M. A., Rual, Jean-François, Vidal, Marc, Blackwell, T. Keith
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916858/
https://www.ncbi.nlm.nih.gov/pubmed/20700440
http://dx.doi.org/10.1371/journal.pgen.1001048

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