Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

Two amino acids (lysine at position 627 or asparagine at position 701) in the polymerase subunit PB2 protein are considered critical for the adaptation of avian influenza A viruses to mammals. However, the recently emerged pandemic H1N1 viruses lack these amino acids. Here, we report that a basic am...

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Detalles Bibliográficos
Autores principales: Yamada, Shinya, Hatta, Masato, Staker, Bart L., Watanabe, Shinji, Imai, Masaki, Shinya, Kyoko, Sakai-Tagawa, Yuko, Ito, Mutsumi, Ozawa, Makoto, Watanabe, Tokiko, Sakabe, Saori, Li, Chengjun, Kim, Jin Hyun, Myler, Peter J., Phan, Isabelle, Raymond, Amy, Smith, Eric, Stacy, Robin, Nidom, Chairul A., Lank, Simon M., Wiseman, Roger W., Bimber, Benjamin N., O'Connor, David H., Neumann, Gabriele, Stewart, Lance J., Kawaoka, Yoshihiro
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916879/
https://www.ncbi.nlm.nih.gov/pubmed/20700447
http://dx.doi.org/10.1371/journal.ppat.1001034

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