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The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis

In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments,...

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Autores principales: Heimel, Kai, Scherer, Mario, Vranes, Miroslav, Wahl, Ramon, Pothiratana, Chetsada, Schuler, David, Vincon, Volker, Finkernagel, Florian, Flor-Parra, Ignacio, Kämper, Jörg
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916880/
https://www.ncbi.nlm.nih.gov/pubmed/20700446
http://dx.doi.org/10.1371/journal.ppat.1001035
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author Heimel, Kai
Scherer, Mario
Vranes, Miroslav
Wahl, Ramon
Pothiratana, Chetsada
Schuler, David
Vincon, Volker
Finkernagel, Florian
Flor-Parra, Ignacio
Kämper, Jörg
author_facet Heimel, Kai
Scherer, Mario
Vranes, Miroslav
Wahl, Ramon
Pothiratana, Chetsada
Schuler, David
Vincon, Volker
Finkernagel, Florian
Flor-Parra, Ignacio
Kämper, Jörg
author_sort Heimel, Kai
collection PubMed
description In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments, induces a G2 cell cycle arrest, and triggers pathogenicity. Here, we identify a set of 345 bE/bW responsive genes which show altered expression during these developmental changes; several of these genes are associated with cell cycle coordination, morphogenesis and pathogenicity. 90% of the genes that show altered expression upon bE/bW-activation require the zinc finger transcription factor Rbf1, one of the few factors directly regulated by the bE/bW heterodimer. Rbf1 is a novel master regulator in a multilayered network of transcription factors that facilitates the complex regulatory traits of sexual and pathogenic development.
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spelling pubmed-29168802010-08-10 The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis Heimel, Kai Scherer, Mario Vranes, Miroslav Wahl, Ramon Pothiratana, Chetsada Schuler, David Vincon, Volker Finkernagel, Florian Flor-Parra, Ignacio Kämper, Jörg PLoS Pathog Research Article In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments, induces a G2 cell cycle arrest, and triggers pathogenicity. Here, we identify a set of 345 bE/bW responsive genes which show altered expression during these developmental changes; several of these genes are associated with cell cycle coordination, morphogenesis and pathogenicity. 90% of the genes that show altered expression upon bE/bW-activation require the zinc finger transcription factor Rbf1, one of the few factors directly regulated by the bE/bW heterodimer. Rbf1 is a novel master regulator in a multilayered network of transcription factors that facilitates the complex regulatory traits of sexual and pathogenic development. Public Library of Science 2010-08-05 /pmc/articles/PMC2916880/ /pubmed/20700446 http://dx.doi.org/10.1371/journal.ppat.1001035 Text en Heimel et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Heimel, Kai
Scherer, Mario
Vranes, Miroslav
Wahl, Ramon
Pothiratana, Chetsada
Schuler, David
Vincon, Volker
Finkernagel, Florian
Flor-Parra, Ignacio
Kämper, Jörg
The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis
title The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis
title_full The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis
title_fullStr The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis
title_full_unstemmed The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis
title_short The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis
title_sort transcription factor rbf1 is the master regulator for b-mating type controlled pathogenic development in ustilago maydis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916880/
https://www.ncbi.nlm.nih.gov/pubmed/20700446
http://dx.doi.org/10.1371/journal.ppat.1001035
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