Cargando…

A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

A protective vaccine against HIV-1 will likely require the elicitation of a broadly neutralizing antibody (bNAb) response. Although the development of an immunogen that elicits such antibodies remains elusive, a proportion of HIV-1 infected individuals evolve broadly neutralizing serum responses ove...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walker, Laura M., Simek, Melissa D., Priddy, Frances, Gach, Johannes S., Wagner, Denise, Zwick, Michael B., Phogat, Sanjay K., Poignard, Pascal, Burton, Dennis R.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916884/ https://www.ncbi.nlm.nih.gov/pubmed/20700449 http://dx.doi.org/10.1371/journal.ppat.1001028

Ejemplares similares

P04-51 LB. The epitopes of two newly identified broad and potent neutralizing antibodies, PG9 and PG16
por: Walker, L, et al.
Publicado: (2009)

Broad neutralization coverage of HIV by multiple highly potent antibodies
por: Walker, Laura M., et al.
Publicado: (2011)

S021-06 OA. Potent and broad neutralizing antibodies from HIV-1 non-clade B infected donor reveal a new HIV-1 vaccine target
por: Phogat, SK, et al.
Publicado: (2009)

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies
por: Julien, J, et al.
Publicado: (2012)

Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies
por: Krumm, Stefanie A., et al.
Publicado: (2016)

A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1
por: Gach, Johannes S., et al.
Publicado: (2013)

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies
por: McCoy, Laura E., et al.
Publicado: (2015)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
por: Shingai, Masashi, et al.
Publicado: (2014)

Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers
por: Hessell, Ann J., et al.
Publicado: (2009)

S021-05 OA. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface
por: Song, L, et al.
Publicado: (2009)

Identification of a clade A HIV envelope immunogen from Protocol G that elicits neutralizing antibodies to tier 2 viruses
por: Hoffenberg, S, et al.
Publicado: (2012)

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
por: Sok, Devin, et al.
Publicado: (2013)

Computational Prediction of Broadly Neutralizing HIV-1 Antibody Epitopes from Neutralization Activity Data
por: Ferguson, Andrew L., et al.
Publicado: (2013)

Correction: The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
por: Sok, Devin, et al.
Publicado: (2013)

Identification and specificity of broadly neutralizing antibodies against HIV
por: McCoy, Laura E., et al.
Publicado: (2017)

Design clues from functional constraints and broadly neutralizing antibodies
por: Zhou, Tongqing, et al.
Publicado: (2006)

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort
por: Landais, Elise, et al.
Publicado: (2016)

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope
por: Schoofs, Till, et al.
Publicado: (2019)

Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding
por: He, Linling, et al.
Publicado: (2014)

MAb PGT121 protects against mucosal SHIV challenge in macaques at concentrations corresponding to its highly potent in vitro neutralization capacity
por: Moldt, B, et al.
Publicado: (2012)

Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
por: McCoy, Laura E., et al.
Publicado: (2012)

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
por: Schommers, Philipp, et al.
Publicado: (2020)

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses
por: Walls, Alexandra C., et al.
Publicado: (2021)

Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope
por: Anthony, Colin, et al.
Publicado: (2017)

A welcome burst of human antibodies
por: Zwick, Michael B, et al.
Publicado: (2008)

bNAber: database of broadly neutralizing HIV antibodies
por: Eroshkin, Alexey M., et al.
Publicado: (2014)

Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease
por: Agudelo, Marianna, et al.
Publicado: (2021)

Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan
por: Umotoy, Jeffrey, et al.
Publicado: (2019)

Novel vomputational methods for predicting epitopes of potent and broadly neutralizing HIV-1 antibodies
por: Evans, MC, et al.
Publicado: (2012)

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
por: Huang, Jinghe, et al.
Publicado: (2012)

Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers
por: Hehle, Verena, et al.
Publicado: (2020)

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents
por: Cao, Yunlong, et al.
Publicado: (2022)

HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage
por: Landais, Elise, et al.
Publicado: (2017)

An MPER antibody neutralizes HIV-1 using germline features shared among donors
por: Zhang, Lei, et al.
Publicado: (2019)

A Highly Potent and Broadly Neutralizing H1 Influenza-Specific Human Monoclonal Antibody
por: Nogales, Aitor, et al.
Publicado: (2018)

1231. VIR-2482: A potent and broadly neutralizing antibody for the prophylaxis of influenza A illness
por: Pizzuto, Matteo Samuele, et al.
Publicado: (2020)

Fusion Proteins CLD and CLDmut Demonstrate Potent and Broad Neutralizing Activity against HIV-1
por: Fu, Ming, et al.
Publicado: (2022)

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity
por: Chen, Wei-Hung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9tmkrsej5hn15codk94sog21td