Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes

Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of non-coding RNA genes by RNA polymerase (pol) III is less well characterized. Here we profile the epigenetic features of pol III target genes throughout...

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Autores principales: Barski, Artem, Chepelev, Iouri, Liko, Dritan, Cuddapah, Suresh, Fleming, Alastair B., Birch, Joanna, Cui, Kairong, White, Robert J., Zhao, Keji
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917008/
https://www.ncbi.nlm.nih.gov/pubmed/20418881
http://dx.doi.org/10.1038/nsmb.1806
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author Barski, Artem
Chepelev, Iouri
Liko, Dritan
Cuddapah, Suresh
Fleming, Alastair B.
Birch, Joanna
Cui, Kairong
White, Robert J.
Zhao, Keji
author_facet Barski, Artem
Chepelev, Iouri
Liko, Dritan
Cuddapah, Suresh
Fleming, Alastair B.
Birch, Joanna
Cui, Kairong
White, Robert J.
Zhao, Keji
author_sort Barski, Artem
collection PubMed
description Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of non-coding RNA genes by RNA polymerase (pol) III is less well characterized. Here we profile the epigenetic features of pol III target genes throughout the human genome. This reveals that the chromatin landscape of pol III-transcribed genes resembles that of pol II templates in many ways, although there are also clear differences. Our analysis also discovered an entirely unexpected phenomenon, namely that pol II is present at the majority of genomic loci that are bound by pol III.
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spelling pubmed-29170082010-11-01 Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes Barski, Artem Chepelev, Iouri Liko, Dritan Cuddapah, Suresh Fleming, Alastair B. Birch, Joanna Cui, Kairong White, Robert J. Zhao, Keji Nat Struct Mol Biol Article Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of non-coding RNA genes by RNA polymerase (pol) III is less well characterized. Here we profile the epigenetic features of pol III target genes throughout the human genome. This reveals that the chromatin landscape of pol III-transcribed genes resembles that of pol II templates in many ways, although there are also clear differences. Our analysis also discovered an entirely unexpected phenomenon, namely that pol II is present at the majority of genomic loci that are bound by pol III. 2010-04-25 2010-05 /pmc/articles/PMC2917008/ /pubmed/20418881 http://dx.doi.org/10.1038/nsmb.1806 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Barski, Artem
Chepelev, Iouri
Liko, Dritan
Cuddapah, Suresh
Fleming, Alastair B.
Birch, Joanna
Cui, Kairong
White, Robert J.
Zhao, Keji
Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes
title Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes
title_full Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes
title_fullStr Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes
title_full_unstemmed Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes
title_short Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes
title_sort pol ii and its associated epigenetic marks are present at pol iii-transcribed non-coding rna genes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917008/
https://www.ncbi.nlm.nih.gov/pubmed/20418881
http://dx.doi.org/10.1038/nsmb.1806
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