At last, a predictive and prognostic marker for radiotherapy?

Holliday junction recognition protein (HJURP) levels in breast cancer associate with both poor prognosis and an increased sensitivity to irradiation. Whilst, in part, this could be explained in relation to proliferation, it would not entirely account for the association with sensitivity to radiation...

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Detalles Bibliográficos
Autores principales: Coates, Philip, Dewar, John, Thompson, Alastair M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917011/
https://www.ncbi.nlm.nih.gov/pubmed/20497617
http://dx.doi.org/10.1186/bcr2567
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author Coates, Philip
Dewar, John
Thompson, Alastair M
author_facet Coates, Philip
Dewar, John
Thompson, Alastair M
author_sort Coates, Philip
collection PubMed
description Holliday junction recognition protein (HJURP) levels in breast cancer associate with both poor prognosis and an increased sensitivity to irradiation. Whilst, in part, this could be explained in relation to proliferation, it would not entirely account for the association with sensitivity to radiation. Thus, HJURP may have clinical potential as a marker of prognosis and radiation sensitivity; further validation with tissues from randomised controlled trials is needed. HJURP may represent the first in a class of proteins with roles in chromosome segregation and DNA repair that act as predictive biomarkers.
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spelling pubmed-29170112010-11-11 At last, a predictive and prognostic marker for radiotherapy? Coates, Philip Dewar, John Thompson, Alastair M Breast Cancer Res Editorial Holliday junction recognition protein (HJURP) levels in breast cancer associate with both poor prognosis and an increased sensitivity to irradiation. Whilst, in part, this could be explained in relation to proliferation, it would not entirely account for the association with sensitivity to radiation. Thus, HJURP may have clinical potential as a marker of prognosis and radiation sensitivity; further validation with tissues from randomised controlled trials is needed. HJURP may represent the first in a class of proteins with roles in chromosome segregation and DNA repair that act as predictive biomarkers. BioMed Central 2010 2010-05-11 /pmc/articles/PMC2917011/ /pubmed/20497617 http://dx.doi.org/10.1186/bcr2567 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Editorial
Coates, Philip
Dewar, John
Thompson, Alastair M
At last, a predictive and prognostic marker for radiotherapy?
title At last, a predictive and prognostic marker for radiotherapy?
title_full At last, a predictive and prognostic marker for radiotherapy?
title_fullStr At last, a predictive and prognostic marker for radiotherapy?
title_full_unstemmed At last, a predictive and prognostic marker for radiotherapy?
title_short At last, a predictive and prognostic marker for radiotherapy?
title_sort at last, a predictive and prognostic marker for radiotherapy?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917011/
https://www.ncbi.nlm.nih.gov/pubmed/20497617
http://dx.doi.org/10.1186/bcr2567
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AT dewarjohn atlastapredictiveandprognosticmarkerforradiotherapy
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