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Tumour-associated carbohydrate antigens in breast cancer

Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhes...

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Detalles Bibliográficos
Autores principales: Cazet, Aurélie, Julien, Sylvain, Bobowski, Marie, Burchell, Joy, Delannoy, Philippe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917018/
https://www.ncbi.nlm.nih.gov/pubmed/20550729
http://dx.doi.org/10.1186/bcr2577
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author Cazet, Aurélie
Julien, Sylvain
Bobowski, Marie
Burchell, Joy
Delannoy, Philippe
author_facet Cazet, Aurélie
Julien, Sylvain
Bobowski, Marie
Burchell, Joy
Delannoy, Philippe
author_sort Cazet, Aurélie
collection PubMed
description Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed.
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spelling pubmed-29170182010-12-08 Tumour-associated carbohydrate antigens in breast cancer Cazet, Aurélie Julien, Sylvain Bobowski, Marie Burchell, Joy Delannoy, Philippe Breast Cancer Res Review Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed. BioMed Central 2010 2010-06-08 /pmc/articles/PMC2917018/ /pubmed/20550729 http://dx.doi.org/10.1186/bcr2577 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Review
Cazet, Aurélie
Julien, Sylvain
Bobowski, Marie
Burchell, Joy
Delannoy, Philippe
Tumour-associated carbohydrate antigens in breast cancer
title Tumour-associated carbohydrate antigens in breast cancer
title_full Tumour-associated carbohydrate antigens in breast cancer
title_fullStr Tumour-associated carbohydrate antigens in breast cancer
title_full_unstemmed Tumour-associated carbohydrate antigens in breast cancer
title_short Tumour-associated carbohydrate antigens in breast cancer
title_sort tumour-associated carbohydrate antigens in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917018/
https://www.ncbi.nlm.nih.gov/pubmed/20550729
http://dx.doi.org/10.1186/bcr2577
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