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Tumour-associated carbohydrate antigens in breast cancer
Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhes...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917018/ https://www.ncbi.nlm.nih.gov/pubmed/20550729 http://dx.doi.org/10.1186/bcr2577 |
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author | Cazet, Aurélie Julien, Sylvain Bobowski, Marie Burchell, Joy Delannoy, Philippe |
author_facet | Cazet, Aurélie Julien, Sylvain Bobowski, Marie Burchell, Joy Delannoy, Philippe |
author_sort | Cazet, Aurélie |
collection | PubMed |
description | Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed. |
format | Text |
id | pubmed-2917018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29170182010-12-08 Tumour-associated carbohydrate antigens in breast cancer Cazet, Aurélie Julien, Sylvain Bobowski, Marie Burchell, Joy Delannoy, Philippe Breast Cancer Res Review Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed. BioMed Central 2010 2010-06-08 /pmc/articles/PMC2917018/ /pubmed/20550729 http://dx.doi.org/10.1186/bcr2577 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Review Cazet, Aurélie Julien, Sylvain Bobowski, Marie Burchell, Joy Delannoy, Philippe Tumour-associated carbohydrate antigens in breast cancer |
title | Tumour-associated carbohydrate antigens in breast cancer |
title_full | Tumour-associated carbohydrate antigens in breast cancer |
title_fullStr | Tumour-associated carbohydrate antigens in breast cancer |
title_full_unstemmed | Tumour-associated carbohydrate antigens in breast cancer |
title_short | Tumour-associated carbohydrate antigens in breast cancer |
title_sort | tumour-associated carbohydrate antigens in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917018/ https://www.ncbi.nlm.nih.gov/pubmed/20550729 http://dx.doi.org/10.1186/bcr2577 |
work_keys_str_mv | AT cazetaurelie tumourassociatedcarbohydrateantigensinbreastcancer AT juliensylvain tumourassociatedcarbohydrateantigensinbreastcancer AT bobowskimarie tumourassociatedcarbohydrateantigensinbreastcancer AT burchelljoy tumourassociatedcarbohydrateantigensinbreastcancer AT delannoyphilippe tumourassociatedcarbohydrateantigensinbreastcancer |