The Human Proteins MBD5 and MBD6 Associate with Heterochromatin but They Do Not Bind Methylated DNA

BACKGROUND: MBD5 and MBD6 are two uncharacterized mammalian proteins that contain a putative Methyl-Binding Domain (MBD). In the proteins MBD1, MBD2, MBD4, and MeCP2, this domain allows the specific recognition of DNA containing methylated cytosine; as a consequence, the proteins serve as interprete...

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Detalles Bibliográficos
Autores principales: Laget, Sophie, Joulie, Michael, Le Masson, Florent, Sasai, Nobuhiro, Christians, Elisabeth, Pradhan, Sriharsa, Roberts, Richard J., Defossez, Pierre-Antoine
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917364/
https://www.ncbi.nlm.nih.gov/pubmed/20700456
http://dx.doi.org/10.1371/journal.pone.0011982

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