A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography

Improved techniques to non-invasively image protein-protein interactions (PPIs) are essential. We molecularly engineered a positron emission tomography (PET)-based split reporter (herpes simplex virus type 1 thymidine kinase [TK]), split between Thr265 and Ala266, and used this in a protein-fragment...

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Detalles Bibliográficos
Autores principales: Massoud, Tarik F., Paulmurugan, Ramasamy, Gambhir, Sanjiv S.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917476/
https://www.ncbi.nlm.nih.gov/pubmed/20639890
http://dx.doi.org/10.1038/nm.2185

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