Lipid accumulation and dendritic cell dysfunction in cancer

Professional antigen presenting cells, dendritic cells (DC) are responsible for initiation and maintenance of immune responses. Here, we report that a substantial proportion of DCs in tumor-bearing mice and cancer patients have increased levels of triglycerides. Lipid accumulation in DCs was caused...

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Detalles Bibliográficos
Autores principales: Herber, Donna L., Cao, Wei, Nefedova, Yulia, Novitskiy, Sergey V., Nagaraj, Srinivas, Tyurin, Vladimir A., Corzo, Alex, Cho, Hyun Il, Celis, Esteban, Lennox, Briana, Knight, Stella C., Padhya, Tapan, McCaffrey, Thomas V., McCaffrey, Judith C., Antonia, Scott, Fishman, Mayer, Ferris, Robert L., Kagan, Valerian E., Gabrilovich, Dmitry I.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917488/
https://www.ncbi.nlm.nih.gov/pubmed/20622859
http://dx.doi.org/10.1038/nm.2172

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