Stevens–Johnson syndrome–toxic epidermal necrolysis (SJS–TEN) overlap associated with carbamazepine use

A benign pruritic rash occurs in 10%–15% of persons treated with carbamazepine. A small fraction of them may experience life-threatening dermatological syndromes such as exfoliative dermatitis, erythema multiforme, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The case of an 1...

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Detalles Bibliográficos
Autores principales: Suresh Kumar, P.N., Thomas, Biju, Kumar, Kishore, Kumar, Shibu
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2005
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918298/
https://www.ncbi.nlm.nih.gov/pubmed/20711297
http://dx.doi.org/10.4103/0019-5545.55961
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author Suresh Kumar, P.N.
Thomas, Biju
Kumar, Kishore
Kumar, Shibu
author_facet Suresh Kumar, P.N.
Thomas, Biju
Kumar, Kishore
Kumar, Shibu
author_sort Suresh Kumar, P.N.
collection PubMed
description A benign pruritic rash occurs in 10%–15% of persons treated with carbamazepine. A small fraction of them may experience life-threatening dermatological syndromes such as exfoliative dermatitis, erythema multiforme, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The case of an 18-year-old female suffering from bipolar affective disorder (mania) who was being treated with carbamazepine, lithium, chlorpromazine and benzhexol is presented. After 10 days of treatment, she developed high-grade fever and mucocutaneous manifestations of SJS–TEN overlap. She was treated in hospital with systemic corticosteroids, antibiotics, intravenous fluids and other supportive measures, and recovered after 3 weeks.
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spelling pubmed-29182982010-08-13 Stevens–Johnson syndrome–toxic epidermal necrolysis (SJS–TEN) overlap associated with carbamazepine use Suresh Kumar, P.N. Thomas, Biju Kumar, Kishore Kumar, Shibu Indian J Psychiatry Case Report A benign pruritic rash occurs in 10%–15% of persons treated with carbamazepine. A small fraction of them may experience life-threatening dermatological syndromes such as exfoliative dermatitis, erythema multiforme, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The case of an 18-year-old female suffering from bipolar affective disorder (mania) who was being treated with carbamazepine, lithium, chlorpromazine and benzhexol is presented. After 10 days of treatment, she developed high-grade fever and mucocutaneous manifestations of SJS–TEN overlap. She was treated in hospital with systemic corticosteroids, antibiotics, intravenous fluids and other supportive measures, and recovered after 3 weeks. Medknow Publications 2005 /pmc/articles/PMC2918298/ /pubmed/20711297 http://dx.doi.org/10.4103/0019-5545.55961 Text en © Indian Journal of Psychiatry http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Suresh Kumar, P.N.
Thomas, Biju
Kumar, Kishore
Kumar, Shibu
Stevens–Johnson syndrome–toxic epidermal necrolysis (SJS–TEN) overlap associated with carbamazepine use
title Stevens–Johnson syndrome–toxic epidermal necrolysis (SJS–TEN) overlap associated with carbamazepine use
title_full Stevens–Johnson syndrome–toxic epidermal necrolysis (SJS–TEN) overlap associated with carbamazepine use
title_fullStr Stevens–Johnson syndrome–toxic epidermal necrolysis (SJS–TEN) overlap associated with carbamazepine use
title_full_unstemmed Stevens–Johnson syndrome–toxic epidermal necrolysis (SJS–TEN) overlap associated with carbamazepine use
title_short Stevens–Johnson syndrome–toxic epidermal necrolysis (SJS–TEN) overlap associated with carbamazepine use
title_sort stevens–johnson syndrome–toxic epidermal necrolysis (sjs–ten) overlap associated with carbamazepine use
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918298/
https://www.ncbi.nlm.nih.gov/pubmed/20711297
http://dx.doi.org/10.4103/0019-5545.55961
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