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Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome
BACKGROUND: Differences in opinion exist among researchers in relation to the course and outcome of substance abuse co-morbidity in schizophrenia. AIM: To compare the pattern of remission of symptoms in positive and negative schizophrenics with and without a history of substance abuse. METHODS: Seve...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918315/ http://dx.doi.org/10.4103/0019-5545.46072 |
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author | Aich, Tapas K. Sinha, Vinod K. Khess, Christoday R.J. Singh, Shailja |
author_facet | Aich, Tapas K. Sinha, Vinod K. Khess, Christoday R.J. Singh, Shailja |
author_sort | Aich, Tapas K. |
collection | PubMed |
description | BACKGROUND: Differences in opinion exist among researchers in relation to the course and outcome of substance abuse co-morbidity in schizophrenia. AIM: To compare the pattern of remission of symptoms in positive and negative schizophrenics with and without a history of substance abuse. METHODS: Seventy schizophrenics were divided into two groups based on the history of presence or absence of substance abuse/dependence. Thirty-eight patients (54.3%) were diagnosed as having co-morbid alcohol/substance abuse/dependence. Patients were rated at two-weekly intervals on the Positive and Negative Syndrome Scale (PANSS) with one follow-up rating by the end of the third month. Co-morbid substance abusers were predominantly represented by a positive syndrome and non-abusers by a negative syndrome at the time of admission. RESULTS: Psychopathology remitted much faster in the substance-abusing group but after discharge, these patients tend to return to their pre-admission state. CONCLUSION: The following hypothesis is proposed based on the findings of the present study: ‘Short-term inpatient outcome of substance-abusing schizophrenics is significantly better than non-substance abusing schizophrenics because of the faster rate of remission of their symptoms.’ A corollary to the above hypothesis may be evolved—‘through intense inpatient follow-up one may be able to differentiate substance-abusing and non-abusing schizophrenics’. |
format | Text |
id | pubmed-2918315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29183152010-08-13 Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome Aich, Tapas K. Sinha, Vinod K. Khess, Christoday R.J. Singh, Shailja Indian J Psychiatry Original Research Paper BACKGROUND: Differences in opinion exist among researchers in relation to the course and outcome of substance abuse co-morbidity in schizophrenia. AIM: To compare the pattern of remission of symptoms in positive and negative schizophrenics with and without a history of substance abuse. METHODS: Seventy schizophrenics were divided into two groups based on the history of presence or absence of substance abuse/dependence. Thirty-eight patients (54.3%) were diagnosed as having co-morbid alcohol/substance abuse/dependence. Patients were rated at two-weekly intervals on the Positive and Negative Syndrome Scale (PANSS) with one follow-up rating by the end of the third month. Co-morbid substance abusers were predominantly represented by a positive syndrome and non-abusers by a negative syndrome at the time of admission. RESULTS: Psychopathology remitted much faster in the substance-abusing group but after discharge, these patients tend to return to their pre-admission state. CONCLUSION: The following hypothesis is proposed based on the findings of the present study: ‘Short-term inpatient outcome of substance-abusing schizophrenics is significantly better than non-substance abusing schizophrenics because of the faster rate of remission of their symptoms.’ A corollary to the above hypothesis may be evolved—‘through intense inpatient follow-up one may be able to differentiate substance-abusing and non-abusing schizophrenics’. Medknow Publications 2005 /pmc/articles/PMC2918315/ http://dx.doi.org/10.4103/0019-5545.46072 Text en © Indian Journal of Psychiatry http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Paper Aich, Tapas K. Sinha, Vinod K. Khess, Christoday R.J. Singh, Shailja Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome |
title | Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome |
title_full | Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome |
title_fullStr | Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome |
title_full_unstemmed | Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome |
title_short | Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome |
title_sort | substance abuse co-morbidity in schizophrenia: an inpatient study of course and outcome |
topic | Original Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918315/ http://dx.doi.org/10.4103/0019-5545.46072 |
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