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Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome

BACKGROUND: Differences in opinion exist among researchers in relation to the course and outcome of substance abuse co-morbidity in schizophrenia. AIM: To compare the pattern of remission of symptoms in positive and negative schizophrenics with and without a history of substance abuse. METHODS: Seve...

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Autores principales: Aich, Tapas K., Sinha, Vinod K., Khess, Christoday R.J., Singh, Shailja
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918315/
http://dx.doi.org/10.4103/0019-5545.46072
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author Aich, Tapas K.
Sinha, Vinod K.
Khess, Christoday R.J.
Singh, Shailja
author_facet Aich, Tapas K.
Sinha, Vinod K.
Khess, Christoday R.J.
Singh, Shailja
author_sort Aich, Tapas K.
collection PubMed
description BACKGROUND: Differences in opinion exist among researchers in relation to the course and outcome of substance abuse co-morbidity in schizophrenia. AIM: To compare the pattern of remission of symptoms in positive and negative schizophrenics with and without a history of substance abuse. METHODS: Seventy schizophrenics were divided into two groups based on the history of presence or absence of substance abuse/dependence. Thirty-eight patients (54.3%) were diagnosed as having co-morbid alcohol/substance abuse/dependence. Patients were rated at two-weekly intervals on the Positive and Negative Syndrome Scale (PANSS) with one follow-up rating by the end of the third month. Co-morbid substance abusers were predominantly represented by a positive syndrome and non-abusers by a negative syndrome at the time of admission. RESULTS: Psychopathology remitted much faster in the substance-abusing group but after discharge, these patients tend to return to their pre-admission state. CONCLUSION: The following hypothesis is proposed based on the findings of the present study: ‘Short-term inpatient outcome of substance-abusing schizophrenics is significantly better than non-substance abusing schizophrenics because of the faster rate of remission of their symptoms.’ A corollary to the above hypothesis may be evolved—‘through intense inpatient follow-up one may be able to differentiate substance-abusing and non-abusing schizophrenics’.
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spelling pubmed-29183152010-08-13 Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome Aich, Tapas K. Sinha, Vinod K. Khess, Christoday R.J. Singh, Shailja Indian J Psychiatry Original Research Paper BACKGROUND: Differences in opinion exist among researchers in relation to the course and outcome of substance abuse co-morbidity in schizophrenia. AIM: To compare the pattern of remission of symptoms in positive and negative schizophrenics with and without a history of substance abuse. METHODS: Seventy schizophrenics were divided into two groups based on the history of presence or absence of substance abuse/dependence. Thirty-eight patients (54.3%) were diagnosed as having co-morbid alcohol/substance abuse/dependence. Patients were rated at two-weekly intervals on the Positive and Negative Syndrome Scale (PANSS) with one follow-up rating by the end of the third month. Co-morbid substance abusers were predominantly represented by a positive syndrome and non-abusers by a negative syndrome at the time of admission. RESULTS: Psychopathology remitted much faster in the substance-abusing group but after discharge, these patients tend to return to their pre-admission state. CONCLUSION: The following hypothesis is proposed based on the findings of the present study: ‘Short-term inpatient outcome of substance-abusing schizophrenics is significantly better than non-substance abusing schizophrenics because of the faster rate of remission of their symptoms.’ A corollary to the above hypothesis may be evolved—‘through intense inpatient follow-up one may be able to differentiate substance-abusing and non-abusing schizophrenics’. Medknow Publications 2005 /pmc/articles/PMC2918315/ http://dx.doi.org/10.4103/0019-5545.46072 Text en © Indian Journal of Psychiatry http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Paper
Aich, Tapas K.
Sinha, Vinod K.
Khess, Christoday R.J.
Singh, Shailja
Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome
title Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome
title_full Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome
title_fullStr Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome
title_full_unstemmed Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome
title_short Substance abuse co-morbidity in schizophrenia: An inpatient study of course and outcome
title_sort substance abuse co-morbidity in schizophrenia: an inpatient study of course and outcome
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918315/
http://dx.doi.org/10.4103/0019-5545.46072
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