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Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), which is characterized by hepatic steatosis, can be reversed by early treatment. Several case reports have indicated that the administration of recombinant growth hormone (GH) could improve fatty liver in GH-deficient patients. Here, we investig...

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Autores principales: Qin, Ying, Tian, Ya-ping
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918616/
https://www.ncbi.nlm.nih.gov/pubmed/20653983
http://dx.doi.org/10.1186/1476-511X-9-78
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author Qin, Ying
Tian, Ya-ping
author_facet Qin, Ying
Tian, Ya-ping
author_sort Qin, Ying
collection PubMed
description BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), which is characterized by hepatic steatosis, can be reversed by early treatment. Several case reports have indicated that the administration of recombinant growth hormone (GH) could improve fatty liver in GH-deficient patients. Here, we investigated whether chronic exogenous GH levels could improve hepatic steatosis induced by a high-fat diet in rats, and explored the underlying mechanisms. RESULTS: High-fat diet-fed rats developed abdominal obesity, fatty liver and insulin resistance. Chronic exogenous GH improved fatty liver, by reversing dyslipidaemia, fat accumulation and insulin resistance. Exogenous GH also reduced serum tumour necrosis factor-alpha (TNF-alpha) levels, and ameliorated hepatic lipid peroxidation and oxidative stress. Hepatic fat deposition was also reduced by exogenous GH levels, as was the expression of adipocyte-derived adipokines (adiponectin, leptin and resistin), which might improve lipid metabolism and hepatic steatosis. Exogenous GH seems to improve fatty liver by reducing fat weight, improving insulin sensitivity and correcting oxidative stress, which may be achieved through phosphorylation or dephosphorylation of a group of signal transducers and activators of hepatic signal transduction pathways. CONCLUSIONS: Chronic exogenous GH has positive effects on fatty liver and may be a potential clinical application in the prevention or reversal of fatty liver. However, chronic secretion of exogenous GH, even at a low level, may increase serum glucose and insulin levels in rats fed a standard diet, and thus increase the risk of insulin resistance.
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spelling pubmed-29186162010-08-10 Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats Qin, Ying Tian, Ya-ping Lipids Health Dis Research BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), which is characterized by hepatic steatosis, can be reversed by early treatment. Several case reports have indicated that the administration of recombinant growth hormone (GH) could improve fatty liver in GH-deficient patients. Here, we investigated whether chronic exogenous GH levels could improve hepatic steatosis induced by a high-fat diet in rats, and explored the underlying mechanisms. RESULTS: High-fat diet-fed rats developed abdominal obesity, fatty liver and insulin resistance. Chronic exogenous GH improved fatty liver, by reversing dyslipidaemia, fat accumulation and insulin resistance. Exogenous GH also reduced serum tumour necrosis factor-alpha (TNF-alpha) levels, and ameliorated hepatic lipid peroxidation and oxidative stress. Hepatic fat deposition was also reduced by exogenous GH levels, as was the expression of adipocyte-derived adipokines (adiponectin, leptin and resistin), which might improve lipid metabolism and hepatic steatosis. Exogenous GH seems to improve fatty liver by reducing fat weight, improving insulin sensitivity and correcting oxidative stress, which may be achieved through phosphorylation or dephosphorylation of a group of signal transducers and activators of hepatic signal transduction pathways. CONCLUSIONS: Chronic exogenous GH has positive effects on fatty liver and may be a potential clinical application in the prevention or reversal of fatty liver. However, chronic secretion of exogenous GH, even at a low level, may increase serum glucose and insulin levels in rats fed a standard diet, and thus increase the risk of insulin resistance. BioMed Central 2010-07-26 /pmc/articles/PMC2918616/ /pubmed/20653983 http://dx.doi.org/10.1186/1476-511X-9-78 Text en Copyright ©2010 Qin and Tian; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Qin, Ying
Tian, Ya-ping
Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats
title Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats
title_full Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats
title_fullStr Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats
title_full_unstemmed Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats
title_short Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats
title_sort preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918616/
https://www.ncbi.nlm.nih.gov/pubmed/20653983
http://dx.doi.org/10.1186/1476-511X-9-78
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