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Small-animal SPECT and SPECT/CT: application in cardiovascular research
Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses ga...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918793/ https://www.ncbi.nlm.nih.gov/pubmed/20069298 http://dx.doi.org/10.1007/s00259-009-1321-8 |
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author | Golestani, Reza Wu, Chao Tio, René A. Zeebregts, Clark J. Petrov, Artiom D. Beekman, Freek J. Dierckx, Rudi A. J. O. Boersma, Hendrikus H. Slart, Riemer H. J. A. |
author_facet | Golestani, Reza Wu, Chao Tio, René A. Zeebregts, Clark J. Petrov, Artiom D. Beekman, Freek J. Dierckx, Rudi A. J. O. Boersma, Hendrikus H. Slart, Riemer H. J. A. |
author_sort | Golestani, Reza |
collection | PubMed |
description | Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease. |
format | Text |
id | pubmed-2918793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-29187932010-08-20 Small-animal SPECT and SPECT/CT: application in cardiovascular research Golestani, Reza Wu, Chao Tio, René A. Zeebregts, Clark J. Petrov, Artiom D. Beekman, Freek J. Dierckx, Rudi A. J. O. Boersma, Hendrikus H. Slart, Riemer H. J. A. Eur J Nucl Med Mol Imaging Review Article Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease. Springer-Verlag 2010-01-13 2010 /pmc/articles/PMC2918793/ /pubmed/20069298 http://dx.doi.org/10.1007/s00259-009-1321-8 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Article Golestani, Reza Wu, Chao Tio, René A. Zeebregts, Clark J. Petrov, Artiom D. Beekman, Freek J. Dierckx, Rudi A. J. O. Boersma, Hendrikus H. Slart, Riemer H. J. A. Small-animal SPECT and SPECT/CT: application in cardiovascular research |
title | Small-animal SPECT and SPECT/CT: application in cardiovascular research |
title_full | Small-animal SPECT and SPECT/CT: application in cardiovascular research |
title_fullStr | Small-animal SPECT and SPECT/CT: application in cardiovascular research |
title_full_unstemmed | Small-animal SPECT and SPECT/CT: application in cardiovascular research |
title_short | Small-animal SPECT and SPECT/CT: application in cardiovascular research |
title_sort | small-animal spect and spect/ct: application in cardiovascular research |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918793/ https://www.ncbi.nlm.nih.gov/pubmed/20069298 http://dx.doi.org/10.1007/s00259-009-1321-8 |
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