Cargando…

Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report

Hemangiopericytoma (HPC) is a rare sarcomatous tumor arising from pericytes, a support cell found in blood vessels. These tumors can occur throughout the body, particularly in the lower extremities and retroperitoneum. In rare circumstances, HPCs can arise from the meninges. In these cases, they beh...

Descripción completa

Detalles Bibliográficos
Autores principales: Peters, Katherine B., McLendon, Roger, Morse, Michael A., Vredenburgh, James J.
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918851/
https://www.ncbi.nlm.nih.gov/pubmed/20740166
http://dx.doi.org/10.1159/000307468
_version_ 1782185153904246784
author Peters, Katherine B.
McLendon, Roger
Morse, Michael A.
Vredenburgh, James J.
author_facet Peters, Katherine B.
McLendon, Roger
Morse, Michael A.
Vredenburgh, James J.
author_sort Peters, Katherine B.
collection PubMed
description Hemangiopericytoma (HPC) is a rare sarcomatous tumor arising from pericytes, a support cell found in blood vessels. These tumors can occur throughout the body, particularly in the lower extremities and retroperitoneum. In rare circumstances, HPCs can arise from the meninges. In these cases, they behave similar to meningiomas, in particular angiomatous meningiomas, but tend to be more aggressive and are likely to recur. Treatment usually focuses on surgical resection and radiotherapy with possible inclusion of chemotherapy for control of recurrent disease. We describe a case of recurrent right temporal HPC that first manifested as a paraneoplastic syndrome of oncogenic osteomalacia. Despite maximum therapy, this patient experienced multiple recurrences of the tumor, and immunohistochemical analysis revealed overexpression of platelet-derived growth factor receptor, a member of the SRC-related tyrosine kinases. After multiple recurrences, the patient's tumor has been stable with treatment with monotherapy utilizing molecularly targeted therapy to SRC-related tyrosine kinases. This is the first case report of the treatment of recurrent meningeal HPC with molecularly targeted therapy to SRC-related tyrosine kinases.
format Text
id pubmed-2918851
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-29188512010-08-25 Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report Peters, Katherine B. McLendon, Roger Morse, Michael A. Vredenburgh, James J. Case Rep Oncol Published: April 2010 Hemangiopericytoma (HPC) is a rare sarcomatous tumor arising from pericytes, a support cell found in blood vessels. These tumors can occur throughout the body, particularly in the lower extremities and retroperitoneum. In rare circumstances, HPCs can arise from the meninges. In these cases, they behave similar to meningiomas, in particular angiomatous meningiomas, but tend to be more aggressive and are likely to recur. Treatment usually focuses on surgical resection and radiotherapy with possible inclusion of chemotherapy for control of recurrent disease. We describe a case of recurrent right temporal HPC that first manifested as a paraneoplastic syndrome of oncogenic osteomalacia. Despite maximum therapy, this patient experienced multiple recurrences of the tumor, and immunohistochemical analysis revealed overexpression of platelet-derived growth factor receptor, a member of the SRC-related tyrosine kinases. After multiple recurrences, the patient's tumor has been stable with treatment with monotherapy utilizing molecularly targeted therapy to SRC-related tyrosine kinases. This is the first case report of the treatment of recurrent meningeal HPC with molecularly targeted therapy to SRC-related tyrosine kinases. S. Karger AG 2010-04-08 /pmc/articles/PMC2918851/ /pubmed/20740166 http://dx.doi.org/10.1159/000307468 Text en Copyright © 2010 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: April 2010
Peters, Katherine B.
McLendon, Roger
Morse, Michael A.
Vredenburgh, James J.
Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report
title Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report
title_full Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report
title_fullStr Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report
title_full_unstemmed Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report
title_short Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report
title_sort treatment of recurrent intracranial hemangiopericytoma with src-related tyrosine kinase targeted therapy: a case report
topic Published: April 2010
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918851/
https://www.ncbi.nlm.nih.gov/pubmed/20740166
http://dx.doi.org/10.1159/000307468
work_keys_str_mv AT peterskatherineb treatmentofrecurrentintracranialhemangiopericytomawithsrcrelatedtyrosinekinasetargetedtherapyacasereport
AT mclendonroger treatmentofrecurrentintracranialhemangiopericytomawithsrcrelatedtyrosinekinasetargetedtherapyacasereport
AT morsemichaela treatmentofrecurrentintracranialhemangiopericytomawithsrcrelatedtyrosinekinasetargetedtherapyacasereport
AT vredenburghjamesj treatmentofrecurrentintracranialhemangiopericytomawithsrcrelatedtyrosinekinasetargetedtherapyacasereport