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Primary Pericardial Mesothelioma: Report of a Patient and Literature Review

Primary mesothelioma of the pericardium is a rare tumor and carries a dismal prognosis. This case report presents a 38-year-old man who suffered from recurrent pericardial fluid. Initial symptoms were unspecific, with dry cough and progressing fatigue. Pericardiocentesis was performed, but analyses...

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Autores principales: Nilsson, Åse, Rasmuson, Torgny
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918860/
https://www.ncbi.nlm.nih.gov/pubmed/20740175
http://dx.doi.org/10.1159/000228894
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author Nilsson, Åse
Rasmuson, Torgny
author_facet Nilsson, Åse
Rasmuson, Torgny
author_sort Nilsson, Åse
collection PubMed
description Primary mesothelioma of the pericardium is a rare tumor and carries a dismal prognosis. This case report presents a 38-year-old man who suffered from recurrent pericardial fluid. Initial symptoms were unspecific, with dry cough and progressing fatigue. Pericardiocentesis was performed, but analyses for malignant cells and tuberculosis were negative. After recurrence a pericardiectomy was planned. At operation, partial resection of tumor tissue surrounding the heart was performed. Histopathologic examination including immunohistochemical staining for calretinin showed a biphasic mesothelioma. During the postoperative period the patient's condition ameliorated, but symptoms recurred and the patient died 3 months after diagnosis and 15 months after the first symptoms. At autopsy, the pericardium was transformed by the tumor that also expanded into the mediastinum and had set metastases to the liver. A review of 29 cases presented in the recent literature indicates a higher incidence of malignant pericardial mesothelioma among men than women. Median age was 46 (range, 19–76) years. In pleural mesotheliomas, exposure to asbestos is a known risk factor. However, in primary pericardial mesotheliomas the evidence for asbestos as an etiologic factor seems to be less convincing (3 exposed among 14 cases). Symptoms are often unspecific and cytologic examination of pericardial fluid is seldom conclusive (malignant cells demonstrated in 4/17 cases). Partial resection of the tumor can give a period of symptom reduction. Only a few patients have been treated with chemotherapy. Median survival of patients with pericardial mesotheliomas is approximately 6 months.
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spelling pubmed-29188602010-08-25 Primary Pericardial Mesothelioma: Report of a Patient and Literature Review Nilsson, Åse Rasmuson, Torgny Case Rep Oncol Published: July 2009 Primary mesothelioma of the pericardium is a rare tumor and carries a dismal prognosis. This case report presents a 38-year-old man who suffered from recurrent pericardial fluid. Initial symptoms were unspecific, with dry cough and progressing fatigue. Pericardiocentesis was performed, but analyses for malignant cells and tuberculosis were negative. After recurrence a pericardiectomy was planned. At operation, partial resection of tumor tissue surrounding the heart was performed. Histopathologic examination including immunohistochemical staining for calretinin showed a biphasic mesothelioma. During the postoperative period the patient's condition ameliorated, but symptoms recurred and the patient died 3 months after diagnosis and 15 months after the first symptoms. At autopsy, the pericardium was transformed by the tumor that also expanded into the mediastinum and had set metastases to the liver. A review of 29 cases presented in the recent literature indicates a higher incidence of malignant pericardial mesothelioma among men than women. Median age was 46 (range, 19–76) years. In pleural mesotheliomas, exposure to asbestos is a known risk factor. However, in primary pericardial mesotheliomas the evidence for asbestos as an etiologic factor seems to be less convincing (3 exposed among 14 cases). Symptoms are often unspecific and cytologic examination of pericardial fluid is seldom conclusive (malignant cells demonstrated in 4/17 cases). Partial resection of the tumor can give a period of symptom reduction. Only a few patients have been treated with chemotherapy. Median survival of patients with pericardial mesotheliomas is approximately 6 months. S. Karger AG 2009-07-29 /pmc/articles/PMC2918860/ /pubmed/20740175 http://dx.doi.org/10.1159/000228894 Text en Copyright © 2009 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: July 2009
Nilsson, Åse
Rasmuson, Torgny
Primary Pericardial Mesothelioma: Report of a Patient and Literature Review
title Primary Pericardial Mesothelioma: Report of a Patient and Literature Review
title_full Primary Pericardial Mesothelioma: Report of a Patient and Literature Review
title_fullStr Primary Pericardial Mesothelioma: Report of a Patient and Literature Review
title_full_unstemmed Primary Pericardial Mesothelioma: Report of a Patient and Literature Review
title_short Primary Pericardial Mesothelioma: Report of a Patient and Literature Review
title_sort primary pericardial mesothelioma: report of a patient and literature review
topic Published: July 2009
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918860/
https://www.ncbi.nlm.nih.gov/pubmed/20740175
http://dx.doi.org/10.1159/000228894
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