Cargando…

mTOR favors senescence over quiescence in p53-arrested cells

Detalles Bibliográficos
Autor principal:	Schug, Thaddeus T.
Formato:	Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2010
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919250/ https://www.ncbi.nlm.nih.gov/pubmed/20603524

Ejemplares similares

Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
por: Dulic, Vjekoslav
Publicado: (2011)

Awakening p53 in senescent cells using nutlin-3
por: Schug, Thaddeus T.
Publicado: (2009)

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
por: Korotchkina, Lioubov G., et al.
Publicado: (2010)

Decision-making by p53 and mTOR
por: Maki, Carl G.
Publicado: (2010)

The p53 inducing drug dosage may determine quiescence or senescence
por: Lane, David P., et al.
Publicado: (2010)

Another "Janus paradox" of p53: induction of cell senescence versus quiescence
por: Darzynkiewicz, Zbigniew
Publicado: (2010)

Hypoxia, MTOR and autophagy: Converging on senescence or quiescence
por: Blagosklonny, Mikhail V.
Publicado: (2013)

As expected, based on rapamycin-like p53-mediated gerosuppression, mTOR inhibition acts as a checkpoint in p53-mediated tumor suppression
por: Blagosklonny, Mikhail V.
Publicado: (2022)

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
por: Jung, Seung Hee, et al.
Publicado: (2018)

P53 levels govern the choice between senescence and quiescence
por: Meek, David W.
Publicado: (2010)

mTOR and its link to the picture of Dorian Gray - re-activation of mTOR promotes aging
por: Węsierska-Gądek, Józefa
Publicado: (2010)

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer
por: Cao, Guo-dong, et al.
Publicado: (2016)

T memory stem cell formation: Caveat mTOR
por: Fowler, Daniel H., et al.
Publicado: (2016)

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
por: Leontieva, Olga V., et al.
Publicado: (2010)

Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway
por: Ling, Bai, et al.
Publicado: (2023)

Dissecting the role of mTOR complexes in cellular senescence
por: Serrano, Manuel
Publicado: (2012)

Regulation of the mTOR-Rac1 axis in platelet function
por: Aslan, Joseph E., et al.
Publicado: (2012)

Mechanistic insights into the role of mTOR signaling in neuronal differentiation
por: Bateman, Joseph M
Publicado: (2015)

Elucidating the role of Lkb1 and mTOR in adipose tissue
por: Xu, Ziye, et al.
Publicado: (2018)

Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
por: El Maï, Mounir, et al.
Publicado: (2020)

YAP enters the mTOR pathway to promote tuberous sclerosis complex
por: Liang, Ning, et al.
Publicado: (2015)

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition
por: Walters, Hannah E., et al.
Publicado: (2016)

p53 suppresses carcinoma progression by inhibiting mTOR pathway activation
por: Akeno, Nagako, et al.
Publicado: (2014)

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
por: Cayo, Angel, et al.
Publicado: (2021)

mTORC2, the “other” mTOR, is a new player in energy balance regulation
por: Cota, Daniela
Publicado: (2014)

Normalizing a hyperactive mTOR initiates muscle growth during obesity
por: Williamson, David L., et al.
Publicado: (2011)

mTOR inhibition: a double-edged sword in patients with COVID-19?
por: Ghasemnejad-Berenji, Morteza
Publicado: (2021)

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
por: Chen, Chong, et al.
Publicado: (2008)

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
por: Astle, M V, et al.
Publicado: (2012)

mTOR pathway activation in age-related retinal disease
por: Zhao, Chen, et al.
Publicado: (2011)

Targeting Transcription Through Inhibition of TBP
por: Schug, Thaddeus T.
Publicado: (2011)

mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression
por: Kon, Ning, et al.
Publicado: (2021)

Coordination of the AMPK, Akt, mTOR, and p53 Pathways under Glucose Starvation
por: Zhou, Yifan, et al.
Publicado: (2022)

mTOR pathway activation is a favorable prognostic factor in human prostate adenocarcinoma
por: Stelloo, Suzan, et al.
Publicado: (2016)

mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines
por: Freis, Patricia, et al.
Publicado: (2017)

Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures
por: Nanba, Daisuke, et al.
Publicado: (2023)

p53 Inhibition Protects against Neuronal Ischemia/Reperfusion Injury by the p53/PRAS40/mTOR Pathway
por: Zhao, Jianlan, et al.
Publicado: (2021)

The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses
por: Cui, Danrui, et al.
Publicado: (2021)

mTOR signaling orchestrates the expression of cytoprotective factors during cellular senescence
por: Yosef, Reut, et al.
Publicado: (2016)

Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
por: Cayo, Angel, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n680vjhbp4pjsbe9qjl9rqggmg